Journal article
In vitro activities of voriconazole, posaconazole, and fluconazole against 4,169 clinical isolates of Candida spp. and Cryptococcus neoformans collected during 2001 and 2002 in the ARTEMIS global antifungal surveillance program
Diagnostic microbiology and infectious disease, Vol.48(3), pp.201-205
2004
DOI: 10.1016/j.diagmicrobio.2003.09.008
PMID: 15023430
Abstract
We examined the in vitro activities of voriconazole, posaconazole, and fluconazole against 3,932 isolates of
Candida spp. and 237 isolates of
Cryptococcus neoformans obtained from over 100 medical centers worldwide during 2001 and 2002. The MICs of the antifungal drugs were determined by broth microdilution tests performed according to the National Committee for Clinical Laboratory Standards (NCCLS) methods using RPMI 1640 as the test medium. Voriconazole and posaconazole were very active against
Candida spp. (97-98% susceptible at MICs ≤1 μg/ml) and
C. neoformans (98-100% susceptible at MICs ≤1 μg/mL).
C. albicans (MIC
90, 0.015-0.03 μg/ml) was the most susceptible species of
Candida to both agents and
C. glabrata (MIC
90, 1-2 μg/mL) was the least susceptible. Both voriconazole and posaconazole were more active than fluconazole against all
Candida spp. and
C. neoformans. These results provide further evidence for the increased spectrum and potency of the new triazoles against a large and geographically diverse collection of opportunistic fungal pathogens.
Details
- Title: Subtitle
- In vitro activities of voriconazole, posaconazole, and fluconazole against 4,169 clinical isolates of Candida spp. and Cryptococcus neoformans collected during 2001 and 2002 in the ARTEMIS global antifungal surveillance program
- Creators
- M.A Pfaller - Department of Pathology, University of Iowa College of Medicine, Iowa City, IA, USAS.A Messer - Department of Pathology, University of Iowa College of Medicine, Iowa City, IA, USAL Boyken - Department of Pathology, University of Iowa College of Medicine, Iowa City, IA, USAR.J Hollis - Department of Pathology, University of Iowa College of Medicine, Iowa City, IA, USAC Rice - Department of Pathology, University of Iowa College of Medicine, Iowa City, IA, USAS Tendolkar - Department of Pathology, University of Iowa College of Medicine, Iowa City, IA, USAD.J Diekema - Department of Pathology, University of Iowa College of Medicine, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Diagnostic microbiology and infectious disease, Vol.48(3), pp.201-205
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.diagmicrobio.2003.09.008
- PMID
- 15023430
- ISSN
- 0732-8893
- eISSN
- 1879-0070
- Language
- English
- Date published
- 2004
- Academic Unit
- Infectious Diseases; Epidemiology; Pathology; Internal Medicine
- Record Identifier
- 9983986263002771
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