Journal article
In vitro activity of ceftaroline against clinical isolates of Streptococcus pneumoniae recovered in 43 U.S. medical centers during 2010-2011
Antimicrobial agents and chemotherapy, Vol.56(6), pp.3406-3408
06/2012
DOI: 10.1128/AAC.00582-12
PMCID: PMC3370772
PMID: 22491687
Abstract
The in vitro activity of ceftaroline, a recently introduced parenteral cephalosporin, was assessed versus 1,750 isolates of Streptococcus pneumoniae recovered from patients with a variety of pneumococcal infections in 43 U.S. medical centers during 2010-2011. Using a breakpoint of ≤ 0.5 μg/ml for susceptibility, all of the isolates were found to be susceptible to ceftaroline. Ceftaroline MICs were consistently 16-fold lower than ceftriaxone MICs. Among the isolates characterized in this investigation, 38.9% were found to be nonsusceptible to penicillin (oral penicillin breakpoints) and 9.1% were nonsusceptible to ceftriaxone (nonmeningitis breakpoints).
Details
- Title: Subtitle
- In vitro activity of ceftaroline against clinical isolates of Streptococcus pneumoniae recovered in 43 U.S. medical centers during 2010-2011
- Creators
- Gary V Doern - Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA. gdoern@nc.rr.comDaniel J DiekemaKristopher P HeilmannCassie L DohrnFathollah RiahiSandra S Richter
- Resource Type
- Journal article
- Publication Details
- Antimicrobial agents and chemotherapy, Vol.56(6), pp.3406-3408
- Publisher
- United States
- DOI
- 10.1128/AAC.00582-12
- PMID
- 22491687
- PMCID
- PMC3370772
- ISSN
- 1098-6596
- eISSN
- 1098-6596
- Language
- English
- Date published
- 06/2012
- Academic Unit
- Infectious Diseases; Epidemiology; Pathology; Internal Medicine
- Record Identifier
- 9983986375002771
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