Journal article
In vitro activity of posaconazole and comparators versus opportunistic filamentous fungal pathogens globally collected during 8 years
Diagnostic microbiology and infectious disease, Vol.101(3), pp.115473-115473
11/2021
DOI: 10.1016/j.diagmicrobio.2021.115473
Abstract
•Over 2,000 moulds collected worldwide from 2010−2017 were susceptibility tested.•Azoles displayed 98.7% categorical agreement when tested against A. fumigatus.•Azole non-wildtype rates of A. fumigatus were higher in Europe.•Azole non-wildtype A. fumigatus increased in Europe from 0% to 5% in 2017.•Posaconazole and amphotericin B were the most active agents against Mucorales.
The epidemiology of invasive filamentous fungal diseases requires monitoring due to changes in susceptibility patterns of new and established antifungal agents that may affect clinical practices. We evaluated the activity of posaconazole against 2,157 invasive moulds collected worldwide from 2010−2017. The isolates included 1,775 Aspergillus spp. and 382 non-Aspergillus moulds, including 81 Fusarium spp., 62 Mucorales group, and 57 Scedosporium spp. Isolates were tested using the CLSI reference broth microdilution method. Posaconazole showed similar activity to itraconazole and voriconazole against A. fumigatus. Applying published ECV, 98.0% of the A. fumigatus and 97.7% to 100.0% of other common Aspergillus species were wildtype to posaconazole. Categorical agreement between posaconazole and the other azoles tested against A. fumigatus was 98.7%. Notably, most of the Aspergillus spp. isolates recovered from this large collection were wildtype to echinocandins and all azoles. Posaconazole non-wildtype rates of A. fumigatus varied across the different geographic regions, with 2.1% in Europe, 2.2% in North America, 1.8% in Latin America, and 0.7% in the Asia-Pacific region. The frequency of azole non-wildtype A. fumigatus isolates from Europe increased steadily from 2010−2017 for all 3 triazoles (0.0%−5.0%). The azole non-wildtype A. fumigatus rates from the other geographic areas were stable over time. Fusarium and/or Scedosporium spp. isolates were highly resistant to azoles and echinocandins. Posaconazole and amphotericin B were the most active agents against the Mucorales. Posaconazole was very active against most species of Aspergillus and was comparable to itraconazole and voriconazole against the less common moulds. Posaconazole should provide a useful addition to the anti-mould grouping of antifungal agents.
Details
- Title: Subtitle
- In vitro activity of posaconazole and comparators versus opportunistic filamentous fungal pathogens globally collected during 8 years
- Creators
- Michael A Pfaller - University of IowaCecilia G Carvalhaes - JMI LaboratoriesShawn A Messer - JMI LaboratoriesPaul R Rhomberg - JMI LaboratoriesMariana Castanheira - JMI Laboratories
- Resource Type
- Journal article
- Publication Details
- Diagnostic microbiology and infectious disease, Vol.101(3), pp.115473-115473
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.diagmicrobio.2021.115473
- ISSN
- 0732-8893
- eISSN
- 1879-0070
- Grant note
- DOI: 10.13039/100009947, name: Merck Sharp and Dohme; DOI: 10.13039/100004334, name: Merck & Co Inc
- Language
- English
- Date published
- 11/2021
- Academic Unit
- Pathology; Epidemiology
- Record Identifier
- 9984185175802771
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