Journal article
In vitro and in silico bioaccessibility of urban dusts contaminated by multiple legacy sources of lead (Pb)
Journal of Hazardous Materials Advances, Vol.8, 100178
11/2022
DOI: 10.1016/j.hazadv.2022.100178
PMCID: PMC10016194
PMID: 36926421
Abstract
•Soil dust from an environmental justice community was assessed for Pb species.•Inhalation and ingestion bioaccessibility of the dust and Pb standards was measured.•Bioaccessibility was dependent on exposure route and Pb species.•Ingestion bioaccessibility exceeded that in lysosomal or lung epithelial fluid.•Bioaccessibility was also modeled and agreed favorably with measured values.
Lead contamination from gasoline, paint, pesticides, and smelting have unique chemical structures. Recent investigations into Pb speciation in urban soils and dusts from multiple sources have revealed emerging forms which differ from the initial sources. This results from reactions with soil constituents leading to transformation to new forms for which the bioaccessibilities remain uninvestigated. We investigated the in vitro and in silico bioaccessibility of these emerging forms in three physiologically relevant milieux: artificial lysosomal fluid (ALF), simulated epithelial lung fluid (SELF), and simulated gastric fluid (SGF). Species were validated using extended X-ray absorption fine structure spectroscopy. Results highlight diverse bioaccessibilities which are form and compartmentally-dependent. In ALF the bioaccessibility trend was humate-bound Pb (86%)> hydrocerussite (79%) >Fe oxide-bound Pb (47%)> galena (10%)>pyromorphite (4%)> Mn oxide-bound Pb (2%). Humate-bound Pb, hydrocerussite, Fe and Mn oxide-bound Pb were 100% bioaccessible in SGF while pyromorphite and galena were 26%, and 8%, respectively. Bioaccessibility in SELF was very low (<1%) and significantly lower than ALF and SGF (p < 0.001). In silico bioaccessibilities modeled using equilibrium solubilities in extraction solutions were in good agreement with empirical measurements. These emerging forms of Pb have a wide range of bioaccessibilities that can influence their toxicity and impact on human health.
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Details
- Title: Subtitle
- In vitro and in silico bioaccessibility of urban dusts contaminated by multiple legacy sources of lead (Pb)
- Creators
- Ezazul Haque - University of IowaXuefang Jing - Department of Occupational and Environmental Health, University of Iowa, IA, USABenjamin C. Bostick - Lamont-Doherty Earth Observatory, Columbia University, New York, NY, USAPeter S. Thorne - Human Toxicology Program, University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Journal of Hazardous Materials Advances, Vol.8, 100178
- DOI
- 10.1016/j.hazadv.2022.100178
- PMID
- 36926421
- PMCID
- PMC10016194
- NLM abbreviation
- J Hazard Mater Adv
- ISSN
- 2772-4166
- Publisher
- Elsevier B.V
- Grant note
- The metals analysis described in this report was funded by the Environmental Health Sciences Research Center, grant NIH P30ES005605. Use of the Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences under Contract No. DE-AC02-76SF00515.
- Language
- English
- Date published
- 11/2022
- Academic Unit
- Civil and Environmental Engineering; Occupational and Environmental Health; Iowa Superfund Research Program
- Record Identifier
- 9984307557102771
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