Journal article
In vitro mutagenicity of the plasmacytomagenic agent pristane (2,6,10,14-tetramethylpentadecane)
Cancer letters, Vol.113(1), pp.71-76
1997
DOI: 10.1016/S0304-3835(97)04597-7
PMID: 9065804
Abstract
Pristane is known to induce a distinct type of B-cell-derived malignant lymphoma, plasmacytoma, after administration into the peritoneal cavity of genetically susceptible BALB/cAnPt mice. Since the mechanism of pristane-induced plasmacytoma development is poorly understood, we chose to examine the possibility that pristane is mutagenic in rodent cells and decided to use bacteriophage λ-derived lacI/lacZ genes as target/reporter to quantitate mutagenesis. Here we show that in vitro exposure to micromolar amounts of pristane, delivered as an inclusion complex with β-cyclodextrin, resulted in 1.7-fold and 6.2-fold increases of mutant frequencies over controls in a cell line of rat fibroblasts and primary mouse B lymphocytes, respectively. We conclude that pristane can be mutagenic to mammalian cells, yet are currently unable to explain the mechanism of mutagenicity. It is suggested that B-cell mutagenesis contributes to the plasmacytomagenic activity of pristane in vivo.
Details
- Title: Subtitle
- In vitro mutagenicity of the plasmacytomagenic agent pristane (2,6,10,14-tetramethylpentadecane)
- Creators
- Klaus Felix - Institut für Klinische Molekularbiologie and Tumorgenetik, GSF, D-81377 München, GermanyMichael Potter - Laboratory of Genetics, DBS, NCI, NIH, Building 37, Room 2B03, Bethesda, MD 20892-4255, USAGeorg-Wilhelm Bornkamm - Institut für Klinische Molekularbiologie and Tumorgenetik, GSF, D-81377 München, GermanySiegfried Janz - Laboratory of Genetics, DBS, NCI, NIH, Building 37, Room 2B03, Bethesda, MD 20892-4255, USA
- Resource Type
- Journal article
- Publication Details
- Cancer letters, Vol.113(1), pp.71-76
- Publisher
- Elsevier Ireland Ltd
- DOI
- 10.1016/S0304-3835(97)04597-7
- PMID
- 9065804
- ISSN
- 0304-3835
- eISSN
- 1872-7980
- Language
- English
- Date published
- 1997
- Academic Unit
- Pathology
- Record Identifier
- 9984083832502771
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