Journal article
In vitro selection of resistance to vancomycin in bloodstream isolates of Staphylococcus haemolyticus and Staphylococcus epidermidis
European journal of clinical microbiology & infectious diseases, Vol.10(12), pp.1007-1012
1991
DOI: 10.1007/BF01984921
PMID: 1802693
Abstract
The purpose of the study was to determine whether vancomycin-resistant strains of Staphylococcus haemolyticus could be selected regardless of the initial MIC of vancomycin. Twenty-one bloodstream isolates of Staphylococcus haemolyticus were studied by broth and agar selection methods. The broth method selected strains for which MICs of vancomycin ranged from 4 to 32 micrograms/ml and MBCs from 16 to greater than 128 micrograms/ml. The agar method selected strains for which MICs ranged from 8 to 32 micrograms/ml and MBCs from 8 to greater than 128 micrograms/ml. For comparison, seven strains of Staphylococcus epidermidis were evaluated by the agar selection method. Final MICs of vancomycin ranged from 8 to 16 micrograms/ml; MBCs ranged from 16 to 64 micrograms/ml. Clearly, in vitro exposure to vancomycin can select strains of Staphylococcus haemolyticus and Staphylococcus epidermidis for which MIC values are beyond the susceptible breakpoint.
Details
- Title: Subtitle
- In vitro selection of resistance to vancomycin in bloodstream isolates of Staphylococcus haemolyticus and Staphylococcus epidermidis
- Creators
- L HERWALDT - Univ. Iowa coll. medicine, dep. internal medicine, Iowa City IA 52242, United StatesL BOYKEN - Univ. Iowa coll. medicine, dep. internal medicine, Iowa City IA 52242, United StatesM PFALLER - Univ. Iowa coll. medicine, dep. internal medicine, Iowa City IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- European journal of clinical microbiology & infectious diseases, Vol.10(12), pp.1007-1012
- Publisher
- Springer
- DOI
- 10.1007/BF01984921
- PMID
- 1802693
- ISSN
- 0934-9723
- eISSN
- 1435-4373
- Language
- English
- Date published
- 1991
- Academic Unit
- Infectious Diseases; Epidemiology; Pathology; Internal Medicine
- Record Identifier
- 9984094636902771
Metrics
14 Record Views