In vitro susceptibility of clinical isolates of Aspergillus spp. to anidulafungin, caspofungin, and micafungin: a head-to-head comparison using the CLSI M38-A2 broth microdilution method

M A Pfaller; L Boyken; R J Hollis; J Kroeger; S A Messer; S Tendolkar; D J Diekema

doi:10.1128/JCM.01155-09

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In vitro susceptibility of clinical isolates of Aspergillus spp. to anidulafungin, caspofungin, and micafungin: a head-to-head comparison using the CLSI M38-A2 broth microdilution method

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In vitro susceptibility of clinical isolates of Aspergillus spp. to anidulafungin, caspofungin, and micafungin: a head-to-head comparison using the CLSI M38-A2 broth microdilution method

M A Pfaller, L Boyken, R J Hollis, J Kroeger, S A Messer, S Tendolkar and D J Diekema

Journal of clinical microbiology, Vol.47(10), pp.3323-3325

10/2009

DOI: 10.1128/JCM.01155-09

PMCID: PMC2756949

PMID: 19710267

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Abstract

We determined the in vitro activities of anidulafungin, caspofungin, and micafungin against 526 isolates of Aspergillus spp. (64 A. flavus, 391 A. fumigatus, 46 A. niger, and 25 A. terreus isolates) collected from over 60 centers worldwide from 2001 through 2007. Susceptibility testing was performed according to the CLSI M38-A2 method. All three echinocandins--anidulafungin (50% minimum effective concentration [MEC50], 0.007 microg/ml; MEC90, 0.015 microg/ml), caspofungin (MEC50, 0.015 microg/ml; MEC90, 0.03 microg/ml), and micafungin (MEC50, 0.007 microg/ml; MEC90, 0.015 microg/ml)-were very active against Aspergillus spp. More than 99% of all isolates were inhibited by < or = 0.06 microg/ml of all three agents.

Antifungal Agents - pharmacology

Lipopeptides - pharmacology

Humans

Aspergillosis - microbiology

Aspergillus - isolation & purification

Inhibitory Concentration 50

Microbial Sensitivity Tests - methods

Echinocandins - pharmacology

Aspergillus - drug effects

Details

Title: Subtitle: In vitro susceptibility of clinical isolates of Aspergillus spp. to anidulafungin, caspofungin, and micafungin: a head-to-head comparison using the CLSI M38-A2 broth microdilution method
Creators: M A Pfaller - Medical Microbiology Division, Department of Pathology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA. michael-pfaller@uiowa.edu
L Boyken
R J Hollis
J Kroeger
S A Messer
S Tendolkar
D J Diekema
Resource Type: Journal article
Publication Details: Journal of clinical microbiology, Vol.47(10), pp.3323-3325
DOI: 10.1128/JCM.01155-09
PMID: 19710267
PMCID: PMC2756949
NLM abbreviation: J Clin Microbiol
ISSN: 0095-1137
eISSN: 1098-660X
Publisher: United States
Language: English
Date published: 10/2009
Academic Unit: Infectious Diseases; Epidemiology; Pathology; Internal Medicine
Record Identifier: 9983986369402771

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