Journal article
In vivo Demonstration of Renal Carbonic Anhydrase Activity in the Fetal Lamb
Neonatology (Basel, Switzerland), Vol.34(5-6), pp.253-258
1978
DOI: 10.1159/000241137
PMID: 32932
Abstract
The capacity of the fetal renal carbonic enzyme to facilitate the renal reabsorption of bicarbonate was studied in 8 long-term fetal lamb preparations (103–124 days of gestation). After acetazolamide administration the fetal arterial blood pH and PC0 2 values decreased significantly (p < 0.05). Significant increases in fetal urinary pH (p < 0.001), and urinary excretion of bicarbonate (p < 0.001), potassium (p < 0.05) and total cation (Na + + K + ) were observed after carbonic anhydrase inhibition. It is suggested from these in vivo studies that renal carbonic anhydrase is present and active during fetal life and does not limit the capacity of the fetal kidney to reabsorb bicarbonate.
Details
- Title: Subtitle
- In vivo Demonstration of Renal Carbonic Anhydrase Activity in the Fetal Lamb
- Creators
- Jean E. Robillard - University of IowaChristine Sessions - University of IowaFred G. Smith Jr
- Resource Type
- Journal article
- Publication Details
- Neonatology (Basel, Switzerland), Vol.34(5-6), pp.253-258
- Publisher
- KARGER; BASEL
- DOI
- 10.1159/000241137
- PMID
- 32932
- ISSN
- 1661-7800
- eISSN
- 1661-7819
- Number of pages
- 6
- Language
- English
- Date published
- 1978
- Academic Unit
- Molecular Physiology and Biophysics; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Medicine Administration
- Record Identifier
- 9984774213102771
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