Journal article
In vivo comparison of phenylephrine and phenylephrine oxazolidine instilled in the monkey eye
Journal of ocular pharmacology, Vol.3(4), pp.333-340
1987
DOI: 10.1089/jop.1987.3.333
PMID: 3503921
Abstract
The ocular and cardiovascular effects as well as aqueous humor and plasma concentrations of 10% phenylephrine HCl and 1% phenylephrine oxazolidine (prodrug) were compared in cynomolgus monkeys. A volume of 25 microliters of either drug was administered to one eye followed by blood pressure, pulse, and pupillary measurements at 10 min intervals up to 60 minutes. Careful slit lamp examinations of the anterior segment, indirect ophthalmoscopy of the vitreous and retina, and ERGs were performed at 60 minutes. Four plasma determinations of phenylephrine following administration of either drug were made between 5 and 60 minutes. Measurement of phenylephrine in aqueous humor was also determined at 60 minutes following all other measurements. The maximal pupillary dilation after administration of 1% prodrug (mean + s.d. = 4.4 + 0.5 mm, n = 12) was slightly greater than after administration of phenylephrine 10% (mean + s.d. = 3.9 + 0.8 mm, n = 12). The differences in pupillary diameter from 20 through 40 minutes were statistically greater for the prodrug. The greater pupillary diameter at the earlier times resulted in an onset of pupillary dilation approximately 15 minutes earlier for the 1% prodrug. There was no ocular toxicity from either drug. Neither drug resulted in any ERG changes compared to baseline. Significantly higher aqueous humor levels along with lower plasma levels were detected and found to be statistically different following administration of the 1% prodrug when compared to 10% phenylephrine.
Details
- Title: Subtitle
- In vivo comparison of phenylephrine and phenylephrine oxazolidine instilled in the monkey eye
- Creators
- R D Schoenwald - College of Pharmacy, University of Iowa, Iowa CityJ C FolkViney KumarJeffery G Piper
- Resource Type
- Journal article
- Publication Details
- Journal of ocular pharmacology, Vol.3(4), pp.333-340
- Publisher
- United States
- DOI
- 10.1089/jop.1987.3.333
- PMID
- 3503921
- ISSN
- 8756-3320
- eISSN
- 1557-7732
- Language
- English
- Date published
- 1987
- Academic Unit
- Pharmacy; Ophthalmology and Visual Sciences
- Record Identifier
- 9983980294602771
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