Journal article
In vivo developmental stages in murine natural killer cell maturation
Nature immunology, Vol.3(6), pp.523-528
06/2002
DOI: 10.1038/ni796
PMID: 12006976
Abstract
Natural killer (NK) cells develop in the bone marrow, but their in vivo stages of maturation, expansion and acquisition of receptors that guide target cell specificity are not well defined. We describe here such stages of development. We also show that developing NK cells actively proliferate at a phenotypically distinguishable immature stage after they have acquired expression of Ly49 and CD94-NKG2 receptors. These studies provide a developmental framework for NK cell maturation in vivo and suggest the possible involvement of the Ly49 and CD94-NKG2 receptors themselves in modulating expansion of NK cell populations with a given NK cell receptor repertoire.
Details
- Title: Subtitle
- In vivo developmental stages in murine natural killer cell maturation
- Creators
- Wayne M Yokoyama - Washington University in St. LouisSungjin Kim - Howard Hughes Medical Institute and Rheumatology Division, Department of Internal Medicine, Barnes-Jewish Hospital and Washington University School of MedicineKoho Iizuka - Washington University in St. LouisHyun-Seok P Kang - Howard Hughes Medical Institute and Rheumatology Division, Department of Internal Medicine, Barnes-Jewish Hospital and Washington University School of MedicineAyotunde Dokun - Howard Hughes Medical Institute and Rheumatology Division, Department of Internal Medicine, Barnes-Jewish Hospital and Washington University School of MedicineAnthony R French - Washington University in St. LouisSuellen Greco - Washington University in St. Louis
- Resource Type
- Journal article
- Publication Details
- Nature immunology, Vol.3(6), pp.523-528
- DOI
- 10.1038/ni796
- PMID
- 12006976
- ISSN
- 1529-2908
- eISSN
- 1529-2916
- Language
- English
- Date published
- 06/2002
- Academic Unit
- Molecular Physiology and Biophysics; Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984297598002771
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