In vivo evidence of cerebellar atrophy and cerebral white matter loss in Huntington disease

C FENNEMA-NOTESTINE; S. L ARCHIBALD; M. W JACOBSON; J COREY-BLOOM; J. S PAULSEN; G. M PEAVY; A. C GAMST; J. M HAMILTON; D. P SALMON; T. L JERNIGAN

doi:10.1212/01.WNL.0000138434.68093.67

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In vivo evidence of cerebellar atrophy and cerebral white matter loss in Huntington disease

Journal article

Peer reviewed

In vivo evidence of cerebellar atrophy and cerebral white matter loss in Huntington disease

C FENNEMA-NOTESTINE, S. L ARCHIBALD, M. W JACOBSON, J COREY-BLOOM, J. S PAULSEN, G. M PEAVY, A. C GAMST, J. M HAMILTON, D. P SALMON and T. L JERNIGAN

Neurology, Vol.63(6), pp.989-995

2004

DOI: 10.1212/01.WNL.0000138434.68093.67

PMID: 15452288

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Abstract

Objective: To investigate the regional pattern of white matter and cerebellar changes, as well as subcortical and cortical changes, in Huntington disease (HD) using morphometric analyses of structural MRI. Methods: Fifteen individuals with HD and 22 controls were studied; groups were similar in age and education. Primary analyses defined six subcortical regions, the gray and white matter of primary cortical lobes and cerebellum, and abnormal signal in the cerebral white matter. Results: As expected, basal ganglia and cerebral cortical gray matter volumes were significantly smaller in HD. The HD group also demonstrated significant cerebral white matter loss and an increase in the amount of abnormal signal in the white matter; occipital white matter appeared more affected than other cerebral white matter regions. Cortical gray and white matter measures were significantly related to caudate volume. Cerebellar gray and white matter volumes were both smaller in HD. Conclusions: The cerebellum and the integrity of cerebral white matter may play a more significant role in the symptomatology of HD than previously thought. Furthermore, changes in cortical gray and cerebral white matter were related to caudate atrophy, supporting a similar mechanism of degeneration.

Neurology

Biological and medical sciences

Vascular diseases and vascular malformations of the nervous system

Medical sciences

Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases

Details

Title: Subtitle: In vivo evidence of cerebellar atrophy and cerebral white matter loss in Huntington disease
Creators: C FENNEMA-NOTESTINE - Veterans Affairs San Diego Healthcare System, CA, United States
S. L ARCHIBALD - Veterans Affairs San Diego Healthcare System, CA, United States
M. W JACOBSON - Veterans Affairs San Diego Healthcare System, CA, United States
J COREY-BLOOM - Department of Neurosciences, University of California, San Diego, La Jolla, United States
J. S PAULSEN - Departments of Psychiatry and Neurology, The University of Iowa, Iowa City, United States
G. M PEAVY - Department of Neurosciences, University of California, San Diego, La Jolla, United States
A. C GAMST - Department of Neurosciences, University of California, San Diego, La Jolla, United States
J. M HAMILTON - Department of Neurosciences, University of California, San Diego, La Jolla, United States
D. P SALMON - Department of Neurosciences, University of California, San Diego, La Jolla, United States
T. L JERNIGAN - Veterans Affairs San Diego Healthcare System, CA, United States
Resource Type: Journal article
Publication Details: Neurology, Vol.63(6), pp.989-995
Publisher: Lippincott Williams & Wilkins
DOI: 10.1212/01.WNL.0000138434.68093.67
PMID: 15452288
ISSN: 0028-3878
eISSN: 1526-632X
Language: English
Date published: 2004
Academic Unit: Psychiatry; Psychological and Brain Sciences
Record Identifier: 9984083228102771

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