In vivo measurement of translational stiffness of rabbit knees

Anneliese D Heiner; M James Rudert; Todd O McKinley; Douglas C Fredericks; John A Bobst; Yuki Tochigi

doi:10.1016/j.jbiomech.2006.10.036

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In vivo measurement of translational stiffness of rabbit knees

Journal article

Peer reviewed

In vivo measurement of translational stiffness of rabbit knees

Anneliese D Heiner, M James Rudert, Todd O McKinley, Douglas C Fredericks, John A Bobst and Yuki Tochigi

Journal of biomechanics, Vol.40(10), pp.2313-2317

01/01/2007

DOI: 10.1016/j.jbiomech.2006.10.036

PMCID: PMC2080615

PMID: 17174958

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https://www.ncbi.nlm.nih.gov/pmc/articles/2080615View

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Abstract

This paper describes the design, evaluation, and preliminary results of a specialized testing device and surgical protocol to determine translational stiffness of a rabbit knee, replicating the clinical anterior drawer test. Coronal-plane transverse pins are inserted through the rabbit leg, two in the tibia and one in the distal femur, to hold and reproducibly position the leg in the device for tests at multiple time points. A linear stepper motor draws the tibia upward then returns to the home position, and a load cell measures the resisting force; force-displacement knee stiffness is then calculated. Initial evaluation of this testing device determined the effects of preconditioning, intra-operator repeatability, rabbit-to-rabbit variability, knee flexion angle (90 degrees vs. 135 degrees ), and anterior cruciate ligament (ACL) sectioning (0%, 25%, 50%, 75%, 100%). Knee stiffness generally decreased as ACL sectioning increased. This testing device and surgical protocol provide an objective and efficient method of determining translational rabbit knee stiffness in vivo, and are being used in an ongoing study to evaluate the effect of knee instability (via partial to complete ACL sectioning) on the development of post-traumatic osteoarthritis.

Animals

Anterior Cruciate Ligament - anatomy & histology

Anterior Cruciate Ligament - physiology

Femur - anatomy & histology

Femur - physiology

Knee Joint - anatomy & histology

Knee Joint - physiology

Rabbits

Stress, Mechanical

Tensile Strength

Tibia - anatomy & histology

Tibia - physiology

Weight-Bearing - physiology

Details

Title: Subtitle: In vivo measurement of translational stiffness of rabbit knees
Creators: Anneliese D Heiner - University of Iowa
M James Rudert
Todd O McKinley - University of Iowa
Douglas C Fredericks - University of Iowa
John A Bobst - University of Iowa
Yuki Tochigi - University of Iowa
Resource Type: Journal article
Publication Details: Journal of biomechanics, Vol.40(10), pp.2313-2317
DOI: 10.1016/j.jbiomech.2006.10.036
PMID: 17174958
PMCID: PMC2080615
NLM abbreviation: J Biomech
ISSN: 0021-9290
eISSN: 1873-2380
Grant note: 5P50 AR 048939 / NIAMS NIH HHS R49 CCR 721745 / PHS HHS P50 AR048939 / NIAMS NIH HHS
Language: English
Date published: 01/01/2007
Academic Unit: Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center
Record Identifier: 9985035879202771

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