In vivo micro-CT lung imaging via a computer-controlled intermittent iso-pressure breath hold (IIBH) technique

E Namati; D Chon; J Thiesse; E A Hoffman; J de Ryk; A Ross; G McLennan

doi:10.1088/0031-9155/51/23/008

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In vivo micro-CT lung imaging via a computer-controlled intermittent iso-pressure breath hold (IIBH) technique

Journal article

Peer reviewed

In vivo micro-CT lung imaging via a computer-controlled intermittent iso-pressure breath hold (IIBH) technique

E Namati, D Chon, J Thiesse, E A Hoffman, J de Ryk, A Ross and G McLennan

Physics in medicine & biology, Vol.51(23), pp.6061-6075

12/07/2006

DOI: 10.1088/0031-9155/51/23/008

PMID: 17110770

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Abstract

Respiratory research with mice using micro-computed tomography (micro-CT) has been predominantly hindered by the limited resolution and signal-to-noise ratio (SNR) as a result of respiratory motion artefacts. In this study, we develop a novel technique for capturing the lung microstructure in vivo using micro-CT, through a computer-controlled intermittent iso-pressure breath hold (IIBH), to reduce respiratory motion, increasing resolution and SNR of reconstructed images. We compare four gating techniques, i.e. no gating, late expiratory (LE) gating, late inspiratory (LI) gating and finally intermittent iso-pressure breath hold (IIBH) gating. Quantitatively, we compare several common image analysis methods used to extract valuable physiologic and anatomic information from the respiratory system, and show that the IIBH technique produces the most representative and repeatable results.

Reproducibility of Results

Biophysical Phenomena

Mice, Inbred C57BL

Tomography, X-Ray Computed - methods

Lung - diagnostic imaging

Biophysics

Lung - physiology

Lung Volume Measurements

Tomography, X-Ray Computed - statistics & numerical data

Animals

Image Processing, Computer-Assisted

Mice

Respiratory Mechanics

Lung - anatomy & histology

Models, Anatomic

Details

Title: Subtitle: In vivo micro-CT lung imaging via a computer-controlled intermittent iso-pressure breath hold (IIBH) technique
Creators: E Namati - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
D Chon
J Thiesse
E A Hoffman
J de Ryk
A Ross
G McLennan
Resource Type: Journal article
Publication Details: Physics in medicine & biology, Vol.51(23), pp.6061-6075
Publisher: England
DOI: 10.1088/0031-9155/51/23/008
PMID: 17110770
ISSN: 0031-9155
eISSN: 1361-6560
Grant note: HL-064368 / NHLBI NIH HHS S1RR019242 / NCRR NIH HHS
Language: English
Date published: 12/07/2006
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Anesthesia; Internal Medicine
Record Identifier: 9984006463302771

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