Journal article
In vivo mouse studies with bioluminescence tomography
Optics express, Vol.14(17), pp.7801-7809
08/21/2006
DOI: 10.1364/OE.14.007801
PMID: 19529149
Abstract
Bioluminescence tomography (BLT) is a new molecular imaging mode, which is being actively developed to reveal molecular and cellular signatures as labeled by bioluminescent probes in a living small animal. This technology can help diagnose diseases, evaluate therapies, and facilitate drug development with mouse models. In this paper, we describe in vivo mouse experiments with BLT, and propose the reconstruction procedure of bioluminescent sources from optical data measured on the body surface of the mouse using a modality fusion approach. The results show the feasibility of our methodology for localization and quantification of the bioluminescent activities in vivo.
Details
- Title: Subtitle
- In vivo mouse studies with bioluminescence tomography
- Creators
- Ge WangWenxiang CongKumar DurairajXin QianHaiou ShenPatrick SinnEric HoffmanGeoffrey McLennanMichael Henry
- Resource Type
- Journal article
- Publication Details
- Optics express, Vol.14(17), pp.7801-7809
- Publisher
- United States
- DOI
- 10.1364/OE.14.007801
- PMID
- 19529149
- ISSN
- 1094-4087
- eISSN
- 1094-4087
- Language
- English
- Date published
- 08/21/2006
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Molecular Physiology and Biophysics; Microbiology and Immunology; Pulmonary Medicine; Stead Family Department of Pediatrics; Pathology; Radiation Oncology; Urology; Internal Medicine
- Record Identifier
- 9984051538402771
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