Journal article
In vivo toxicity evaluation of gold-dendrimer composite nanodevices with different surface charges
Nanotoxicology, Vol.7(4), pp.441-451
06/01/2013
DOI: 10.3109/17435390.2012.668570
PMID: 22394369
Abstract
Composite nanodevices (CNDs) are multifunctional nanomaterials with potential uses in cancer imaging and therapy. Poly(amidoamine) dendrimer-based composite nanodevices are important members of this group and consist of an organic dendrimer component and an incorporated inorganic component, in this case, gold. This study addresses the short- (14 days) and long-term (78 days) in vivo toxicity of generation-5 (G5; 5 nm) PAMAM dendrimer-based gold-CNDs (Au-CNDs) with varying surface charges (positive, negative and neutral) in C57BL/6J male mice. Detailed toxicological analyses of (1) body weight changes, (2) serum chemistry and (3) histopathological examination of 22 organs showed no evidence of organ injury or organ function compromise. Zeta potential of Au-CNDs showed significant change from their parent dendrimers upon gold incorporation, making the normally lethal positive surface dendrimer biologically safe. Also homeostatic mechanisms in vivo may compensate/repair toxic effects, something not seen with in vitro assays.
Details
- Title: Subtitle
- In vivo toxicity evaluation of gold-dendrimer composite nanodevices with different surface charges
- Creators
- Venugopalan Kasturirangan - Roswell Park Cancer InstituteBindu M. Nair - Roswell Park Cancer InstituteMuhammed T. S. Kariapper - Roswell Park Cancer InstituteWojciech G. Lesniak - Roswell Park Cancer InstituteWei Tan - Roswell Park Cancer InstituteRemy Bizimungu - Roswell Park Cancer InstitutePeter Kanter - Roswell Park Cancer InstituteKaroly Toth - Roswell Park Cancer InstituteSandra Buitrago - Roswell Park Cancer InstituteYoucef M. Rustum - Roswell Park Cancer InstituteAlan Hutson - Roswell Park Cancer InstituteLajos P. Balogh - Roswell Park Cancer InstituteMohamed K. Khan - Roswell Park Cancer Institute
- Resource Type
- Journal article
- Publication Details
- Nanotoxicology, Vol.7(4), pp.441-451
- Publisher
- Taylor & Francis
- DOI
- 10.3109/17435390.2012.668570
- PMID
- 22394369
- ISSN
- 1743-5390
- eISSN
- 1743-5404
- Number of pages
- 11
- Grant note
- W81XWH-07-1-0504 / Department of Defense; United States Department of Defense R01CA104479 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) 5R01 CA104479 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 06/01/2013
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359899402771
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