Journal article
Incidence and Survival Among Young Women With Stage I–III Breast Cancer: SEER 2000–2015
JNCI cancer spectrum, Vol.3(3), pp.pkz040-pkz040
09/01/2019
DOI: 10.1093/jncics/pkz040
PMCID: PMC6668585
PMID: 31392297
Abstract
Abstract Background Although recent findings suggest that de novo stage IV breast cancer is increasing in premenopausal women in the United States, contemporary incidence and survival data are lacking for stage I–III cancer. Methods Women aged 20–29 (n = 3826), 30–39 (n = 34 585), and 40–49 (n = 126 552) years who were diagnosed with stage I–III breast cancer from 2000 to 2015 were identified from the Surveillance, Epidemiology, and End Results 18 registries database. Age-adjusted, average annual percentage changes in incidence and 5- and 10-year Kaplan-Meier survival curves were estimated by race and ethnicity, stage, and hormone receptor (HR) status and grade (low to well and moderately differentiated; high to poorly and undifferentiated) for each age decade. Results The average annual percentage change in incidence was positive for each age decade and was highest among women aged 20–29 years. Increased incidence was driven largely by HR+ cancer, particularly HR+ low-grade cancer in women aged 20–29 and 40–49 years. By 2015, incidence of HR+ low- and high-grade cancer each independently exceeded incidence of HR− cancer in each age decade. Survival for HR+ low- and high-grade cancer decreased with decreasing age; survival for HR− cancer was similar across age decades. Among all women aged 20–29 years, 10-year survival for HR+ high-grade cancer was lower than that for HR+ low-grade or HR− cancer. Among women aged 20–29 years with stage I cancer, 10-year survival was lowest for HR+ high-grade cancer. Conclusions HR+ breast cancer is increasing in incidence among premenopausal women, and HR+ high-grade cancer was associated with reduced survival among women aged 20–29 years. Our findings can help guide further evaluation of preventive, diagnostic, and therapeutic strategies for breast cancer among premenopausal women.
Details
- Title: Subtitle
- Incidence and Survival Among Young Women With Stage I–III Breast Cancer: SEER 2000–2015
- Creators
- Alexandra Thomas - Department of Internal Medicine, Wake Forest University School of Medicine, Wake Forest University, Winston-Salem, NCAnthony Rhoads - Department of Epidemiology, College of Public Health, Division of Health Services Research, Department of Biostatistics, , University of Iowa, Iowa City, IAElizabeth Pinkerton - Department of Epidemiology, College of Public Health, Division of Health Services Research, Department of Biostatistics, , University of Iowa, Iowa City, IAMary C Schroeder - College of Pharmacy, University of Iowa, Iowa City, IAKristin M Conway - Department of Epidemiology, College of Public Health, Division of Health Services Research, Department of Biostatistics, , University of Iowa, Iowa City, IAWilliam G Hundley - Department of Internal Medicine, Virginia Commonwealth University, Richmond, VALacey R McNally - Department of Cancer Biology, Wake Forest University School of Medicine, Wake Forest University, Winston-Salem, NCJacob Oleson - College of Public Health, University of Iowa, Iowa City, IA, Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IACharles F Lynch - Department of Epidemiology, College of Public Health, Division of Health Services Research, Department of Biostatistics, , University of Iowa, Iowa City, IAPaul A Romitti - Department of Epidemiology, College of Public Health, Division of Health Services Research, Department of Biostatistics, , University of Iowa, Iowa City, IA, College of Public Health, University of Iowa, Iowa City, IA, Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- JNCI cancer spectrum, Vol.3(3), pp.pkz040-pkz040
- DOI
- 10.1093/jncics/pkz040
- PMID
- 31392297
- PMCID
- PMC6668585
- ISSN
- 2515-5091
- eISSN
- 2515-5091
- Grant note
- DOI: 10.13039/100000030, name: Centers for Disease Control and Prevention, award: U01DD001035, U01DD001223; DOI: 10.13039/100000054, name: National Cancer Institute, award: HHSN2612013000201; name: Nealie Belk Stevens Fund for Breast Cancer Research
- Language
- English
- Date published
- 09/01/2019
- Academic Unit
- Epidemiology; Biostatistics; Pharmacy Practice and Science; Internal Medicine
- Record Identifier
- 9984214788702771
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