Journal article
Incidence and management of pleural effusions in patients with Wilms tumor: A Pediatric Surgical Oncology Research Collaborative study
International journal of cancer, Vol.151(10), pp.1696-1702
11/15/2022
DOI: 10.1002/ijc.34188
PMID: 35748343
Abstract
Wilms tumor (WT) is the most common renal malignancy in children. Children with favorable histology WT achieve survival rates of over 90%. Twelve percent of patients present with metastatic disease, most commonly to the lungs. The presence of a pleural effusion at the time of diagnosis of WT may be noted on staging imaging; however, minimal data exist regarding the significance and prognostic importance of this finding. The objectives of our study are to identify the incidence of pleural effusions in patients with WT, and to determine the potential impact on oncologic outcomes. A multi-institutional retrospective review was performed from January 2009 to December 2019, including children with WT and a pleural effusion on diagnostic imaging treated at Pediatric Surgical Oncology Research Collaborative (PSORC) participating institutions. Of 1259 children with a new WT diagnosis, 94 (7.5%) had a pleural effusion. Patients with a pleural effusion were older than those without (median 4.3 vs 3.5 years; P = .004), and advanced stages were more common (local stage III 85.9% vs 51.9%; P < .0001). Only 14 patients underwent a thoracentesis for fluid evaluation; 3 had cytopathologic evidence of malignant cells. Event-free and overall survival of all children with WT and pleural effusions was 86.2% and 91.5%, respectively. The rate and significance of malignant cells present in pleural fluid is unknown due to low incidence of cytopathologic analysis in our cohort; therefore, the presence of an effusion does not appear to necessitate a change in therapy. Excellent survival can be expected with current stage-specific treatment regimens.
Details
- Title: Subtitle
- Incidence and management of pleural effusions in patients with Wilms tumor: A Pediatric Surgical Oncology Research Collaborative study
- Creators
- Ameer Al-Hadidi - Nationwide Children's HospitalHannah N. Rinehardt - University of PittsburghPattamon Sutthatarn - St. Jude Children's Research HospitalLindsay J. Talbot - St. Jude Children's Research HospitalAndrew J. Murphy - St. Jude Children's Research HospitalRichard Whitlock - Texas Children's HospitalSienna Condon - Baylor College of MedicineBindi Naik-Mathuria - Texas Children's HospitalAlan F. Utria - Seattle Children's HospitalDavid H. Rothstein - Seattle Children's HospitalStephanie Y. Chen - Children's Hospital of Los AngelesShannon Wong-Michalak - Children's Hospital of Los AngelesEugene S. Kim - Children's Hospital of Los AngelesScott S. Short - Primary Children's HospitalRebecka L. Meyers - Primary Children's HospitalZachary J. Kastenberg - Primary Children's HospitalMichael E. Johnston - Cincinnati Children's Hospital Medical CenterTiffany Zens - Cincinnati Children's Hospital Medical CenterRoshni Dasgupta - Cincinnati Children's Hospital Medical CenterMarcus M. Malek - University of PittsburghKristen Calabro - Centre Hospitalier Universitaire Sainte-JustineNelson Piche - Centre Hospitalier Universitaire Sainte-JustineHannah Callas - Northwestern UniversityTimothy B. Lautz - Northwestern UniversityKatlyn McKay - Vanderbilt University Medical CenterHarold N. Lovvorn - Vanderbilt University Medical CenterSarah Jane Commander - Duke Medical CenterElisabeth T. Tracy - Duke Medical CenterSarah B. Lund - Mayo ClinicStephanie F. Polites - Mayo ClinicJacob Davidson - Western UniversityJanel Dhooma - Western UniversityNatashia M. Seemann - Western UniversityJohn P. Marquart - Medical College of WisconsinHaley Gainer - Medical College of WisconsinDave R. Lal - Medical College of WisconsinBarrie S. Rich - Cohen Children's Medical CenterRichard D. Glick - Cohen Children's Medical CenterLauren Maloney - Oregon Health & Science UniversityStephani Radu - Oregon Health & Science UniversityElizabeth A. Fialkowski - Oregon Health & Science UniversityPei En Kwok - Dalhousie UniversityRodrigo L. P. Romao - Dalhousie UniversityNathan Rubalcava - University of MichiganPeter F. Ehrlich - University of MichiganErika Newman - University of MichiganThomas Diehl - University of Wisconsin American Family Children's HospitalHau D. Le - University of Wisconsin American Family Children's HospitalValerie Polcz - University of FloridaRobin T. Petroze - University of FloridaJoseph Stanek - Nationwide Children's HospitalJennifer H. Aldrink - Nationwide Children's Hospital
- Resource Type
- Journal article
- Publication Details
- International journal of cancer, Vol.151(10), pp.1696-1702
- DOI
- 10.1002/ijc.34188
- PMID
- 35748343
- NLM abbreviation
- Int J Cancer
- ISSN
- 0020-7136
- eISSN
- 1097-0215
- Publisher
- Wiley
- Number of pages
- 7
- Language
- English
- Date published
- 11/15/2022
- Academic Unit
- Surgery
- Record Identifier
- 9985014845602771
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