Incidence of Delirium and Associated Mortality in Hematopoietic Stem Cell Transplantation Patients

Leigh J Beglinger; Kevin Duff; Sara Van Der Heiden; Karen Parrott; Douglas Langbehn; Roger Gingrich

doi:10.1016/j.bbmt.2006.05.009

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Incidence of Delirium and Associated Mortality in Hematopoietic Stem Cell Transplantation Patients

Journal article

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Incidence of Delirium and Associated Mortality in Hematopoietic Stem Cell Transplantation Patients

Leigh J Beglinger, Kevin Duff, Sara Van Der Heiden, Karen Parrott, Douglas Langbehn and Roger Gingrich

Biology of blood and marrow transplantation, Vol.12(9), pp.928-935

2006

DOI: 10.1016/j.bbmt.2006.05.009

PMID: 16920558

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Abstract

Delirium has been associated with a high risk of mortality in medical patients. Despite the high incidence of delirium in patients who undergo hemapoietic stem cell transplantation (HSCT), delirium as a risk factor for death has not been examined in this population. Thirty adult patients undergoing HSCT who were admitted to the University of Iowa Blood and Marrow Transplantation Program inpatient unit were assessed prospectively from 1 to 2 weeks before transplantation, throughout their inpatient stay, and at 100 days after transplantation. The Delirium Rating Scale and Memorial Delirium Assessment Scale were used twice weekly during the inpatient period to assess delirium severity and occurence. Patients’ self-reports of medical history, computerized medical records, and neuropsychological and psychiatric assessments were used to identify pretransplantation risk factors. The incidence of delirium (Delirium Rating Scale score >12 or Memorial Delirium Assessment Scale score ≥8) was 43% and occurred with highest frequency in the first 2 weeks after transplantion. The presence of delirium at any point during hospitalization after transplantation and transplant type (allogeneic) were highly predictive of mortality (p < .0005; odds ratios, 14.0 and 14.4). In conclusion, this study highlights the importance of monitoring for delirium during the acute recovery period after transplantation and suggests that early or even prophylactic treatment for delirium should be studied. Studies to determine the factors that connect delerium soon after transplantation to mortality are highly warranted.

Delirium

Bone marrow transplant

Cognition

Mortality

Details

Title: Subtitle: Incidence of Delirium and Associated Mortality in Hematopoietic Stem Cell Transplantation Patients
Creators: Leigh J Beglinger - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa
Kevin Duff - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa
Sara Van Der Heiden - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa
Karen Parrott - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa
Douglas Langbehn - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa
Roger Gingrich - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa
Resource Type: Journal article
Publication Details: Biology of blood and marrow transplantation, Vol.12(9), pp.928-935
DOI: 10.1016/j.bbmt.2006.05.009
PMID: 16920558
NLM abbreviation: Biol Blood Marrow Transplant
ISSN: 1083-8791
eISSN: 1523-6536
Publisher: Elsevier Inc
Language: English
Date published: 2006
Academic Unit: Psychiatry; Iowa Neuroscience Institute; Internal Medicine
Record Identifier: 9984003955702771

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