Journal article
Incidence of Extended-Spectrum β-Lactamase (ESBL)-Producing Escherichia coli and Klebsiella Infections in the United States: A Systematic Literature Review
Infection control and hospital epidemiology, Vol.38(10), pp.1209-1215
10/2017
DOI: 10.1017/ice.2017.156
PMID: 28758612
Abstract
BACKGROUND Despite a reported worldwide increase, the incidence of extended-spectrum β-lactamase (ESBL) Escherichia coli and Klebsiella infections in the United States is unknown. Understanding the incidence and trends of ESBL infections will aid in directing research and prevention efforts. OBJECTIVE To perform a literature review to identify the incidence of ESBL-producing E. coli and Klebsiella infections in the United States. DESIGN Systematic literature review. METHODS MEDLINE via Ovid, CINAHL, Cochrane library, NHS Economic Evaluation Database, Web of Science, and Scopus were searched for multicenter (≥2 sites), US studies published between 2000 and 2015 that evaluated the incidence of ESBL-E. coli or ESBL-Klebsiella infections. We excluded studies that examined resistance rates alone or did not have a denominator that included uninfected patients such as patient days, device days, number of admissions, or number of discharges. Additionally, articles that were not written in English, contained duplicated data, or pertained to ESBL organisms from food, animals, or the environment were excluded. RESULTS Among 51,419 studies examined, 9 were included for review. Incidence rates differed by patient population, time, and ESBL definition and ranged from 0 infections per 100,000 patient days to 16.64 infections per 10,000 discharges and incidence rates increased over time from 1997 to 2011. Rates were slightly higher for ESBL-Klebsiella infections than for ESBL-E. coli infections. CONCLUSION The incidence of ESBL-E. coli and ESBL-Klebsiella infections in the United States has increased, with slightly higher rates of ESBL-Klebsiella infections. Appropriate estimates of ESBL infections when coupled with other mechanisms of resistance will allow for the appropriate targeting of resources toward research, drug discovery, antimicrobial stewardship, and infection prevention. Infect Control Hosp Epidemiol 2017;38:1209-1215.
Details
- Title: Subtitle
- Incidence of Extended-Spectrum β-Lactamase (ESBL)-Producing Escherichia coli and Klebsiella Infections in the United States: A Systematic Literature Review
- Creators
- Jennifer McDanel - 1Department of Internal Medicine,University of Iowa,Iowa City,IowaMarin Schweizer - 1Department of Internal Medicine,University of Iowa,Iowa City,IowaVictoria Crabb - 2Iowa City Veteran Affairs Medical Center,Iowa City,IowaRichard Nelson - 4Department of Clinical Epidemiology,University of Utah,Salt Lake City,UtahMatthew Samore - 4Department of Clinical Epidemiology,University of Utah,Salt Lake City,UtahKarim Khader - 4Department of Clinical Epidemiology,University of Utah,Salt Lake City,UtahAmy E Blevins - 6Hardin Library for the Health Sciences,University of Iowa,Iowa City,IowaDaniel Diekema - 1Department of Internal Medicine,University of Iowa,Iowa City,IowaHsiu-Yin Chiang - 1Department of Internal Medicine,University of Iowa,Iowa City,IowaRajeshwari Nair - 1Department of Internal Medicine,University of Iowa,Iowa City,IowaEli Perencevich - 1Department of Internal Medicine,University of Iowa,Iowa City,Iowa
- Resource Type
- Journal article
- Publication Details
- Infection control and hospital epidemiology, Vol.38(10), pp.1209-1215
- Publisher
- United States
- DOI
- 10.1017/ice.2017.156
- PMID
- 28758612
- ISSN
- 0899-823X
- eISSN
- 1559-6834
- Language
- English
- Date published
- 10/2017
- Academic Unit
- Infectious Diseases; Epidemiology; Pathology; Internal Medicine
- Record Identifier
- 9983779496902771
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