Journal article
Incidence of Interstitial Lung Abnormalities: The MESA Lung Study
The European respiratory journal, Vol.61(6), 2201950
06/01/2023
DOI: 10.1183/13993003.01950-2022
PMCID: PMC10773573
PMID: 37202153
Abstract
The incidence of newly developed interstitial lung abnormalities (ILA) and fibrotic ILA have not been previously reported.Trained thoracic radiologists evaluated 13 944 cardiac CT scans for the presence of ILA in 6197 Multi-Ethnic Study of Atherosclerosis longitudinal cohort study participants >45 years of age from 2000 to 2012. 5% of the scans were re-read by the same or a different observer in a blinded fashion. After exclusion of participants with ILA at baseline, incidence rates and incidence rate ratios for ILA and fibrotic ILA were calculated.The intra-reader agreement of ILA was 92.0% (Gwet AC1=0.912, ICC=0.982) and the inter-reader agreement of ILA was 83.5% (Gwet AC1=0.814; ICC=0.969). Incidence of ILA and fibrotic ILA was estimated to be 13.1 cases/1000 person-years and 3.5/1000 person-years, respectively. In multivariable analyses, age (HR 1.06 (1.05, 1.08), p <0.001; HR 1.08 (1.06, 1.11), p <0.001), high attenuation area (HAA) at baseline (HR 1.05 (1.03, 1.07), p <0.001; HR 1.06 (1.02, 1.10), p=0.002), and the
promoter SNP (HR 1.73 (1.17, 2.56) p=0.01; HR 4.96 (2.68, 9.15), p <0.001) were associated with incident ILA and fibrotic ILA, respectively. Ever smoking (HR 2.31 (1.34, 3.96), p= 0.002) and an IPF polygenic risk score (HR 2.09 (1.61-2.71), p<0.001) were associated only with incident fibrotic ILA.Incident ILA and fibrotic ILA were estimated by review of cardiac imaging studies. These findings may lead to wider application of a screening tool for atherosclerosis to identify preclinical lung disease.
Details
- Title: Subtitle
- Incidence of Interstitial Lung Abnormalities: The MESA Lung Study
- Creators
- Claire F McGroder - Columbia University Irving Medical CenterSpencer Hansen - University of WashingtonKaren Hinckley Stukovsky - University of WashingtonDavid Zhang - Columbia University Irving Medical CenterP Hrudaya Nath - University of AlabamaMary M Salvatore - Columbia University Irving Medical CenterSushilkumar K Sonavane - Department of Radiology, Mayo Clinic at Jacksonville, Jacksonville, FL, USANina Terry - University of AlabamaJustin T Stowell - Department of Radiology, Mayo Clinic at Jacksonville, Jacksonville, FL, USABelinda M D'Souza - Columbia University Irving Medical CenterJay S Leb - Columbia University Irving Medical CenterShifali Dumeer - Columbia University Irving Medical CenterMuhammad U Aziz - University of AlabamaKiran Batra - The University of Texas Southwestern Medical CenterEric A Hoffman - Department of Radiology, University of Iowa, Iowa City, IA, USAElana J Bernstein - Columbia University Irving Medical CenterJohn S Kim - University of VirginiaAnna J Podolanczuk - Cornell UniversityJerome I Rotter - Harbor–UCLA Medical CenterAni W Manichaikul - University of VirginiaStephen S Rich - University of VirginiaDavid J Lederer - Regeneron (United States)R Graham Barr - Columbia University Irving Medical CenterRobyn L McClelland - University of WashingtonChristine Kim Garcia - Columbia University Irving Medical Center
- Resource Type
- Journal article
- Publication Details
- The European respiratory journal, Vol.61(6), 2201950
- DOI
- 10.1183/13993003.01950-2022
- PMID
- 37202153
- PMCID
- PMC10773573
- NLM abbreviation
- Eur Respir J
- ISSN
- 0903-1936
- eISSN
- 1399-3003
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: 3U54HG003067-13S1, contract HHSN268201600034I, N01-HC95159, N01-HC95160, N01-HC95161, N01-HC95162, N01-HC95163, N01-HC95164, N01-HC95165, N01-HC95166, N01-HC95167, N01-HC95168, N01-HC95169, P30-DK063491, UL1-TR000040, UL1-TR001079, UL1-TR001420, UL1-TR001881; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: 3R01HL117626-02S1; contract HHSN268201800002I, K23 HL150301, R01-HL077612, R01-HL103676, R01-HL120393, R01HL105756, RC1-HL100543, T32 HL105323, U01-HL120393; contract HHSN268201800001I; DOI: 10.13039/100000069, name: National Institute of Arthritis and Musculoskeletal and Skin Diseases, award: K23 AR075112
- Language
- English
- Electronic publication date
- 05/18/2023
- Date published
- 06/01/2023
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984413073702771
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