Journal article
Incidence of atrial fibrillation in pregnancy and clinical significance: A meta-analysis
Advances in medical sciences, Vol.64(2), pp.415-422
09/01/2019
DOI: 10.1016/j.advms.2019.07.003
PMID: 31521944
Abstract
Purpose: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia worldwide, and is associated with increased morbidity and mortality. However, the incidence and maternal/fetal outcomes of AF in pregnancy remain unclear. This study's aims were to investigate the pooled incidence of AF in pregnant women and to assess maternal/fetal outcomes of AF in pregnancy.
Material and methods: A literature search for studies that reported incidence of AF in pregnancy, was conducted using MEDLINE, EMBASE and Cochrane Database from inception through May 2018. Pooled incidence with 95%CI were calculated using a random-effect model. The protocol for this meta-analysis is registered with PROSPERO (International Prospective Register of Systematic Reviews; no. CRD42018095955).
Results: We identified 7 cohort studies including 301,638 pregnancies. The pooled estimated incidence of AF in pregnancy among women with no known heart disease, and those with structural heart disease was 0.3% (95%CI: 0.01%-40.6%) and 2.2% (95%CI: 0.96%-5.01%), respectively. Among women with known AF, the pooled estimated incidence of recurrent AF in pregnancy was 39.2% (95%CI: 16.9%-67.2%). The pooled estimated incidence of pre-eclampsia and congestive heart failure among pregnant patients with AF was 4.1% (95%CI: 2.1%-7.8%) and 9.6% (95%CI: 5.7%-15.9%), respectively. The pooled estimated incidence of fetal events including premature birth, small for gestational age, respiratory distress syndrome, intraventricular hemorrhage, death was 26.6% (95%CI: 20.4%-34.0%).
Conclusion: The overall estimated incidence of AF and recurrent AF during pregnancy is as high as 2.2% and 39.2%, respectively. AF during pregnancy may result in poor maternal and fetal outcomes.
Details
- Title: Subtitle
- Incidence of atrial fibrillation in pregnancy and clinical significance: A meta-analysis
- Creators
- Ronpichai Chokesuwattanaskul - King Chulalongkorn Memorial HospitalCharat Thongprayoon - Mayo ClinicTarun Bathini - University of ArizonaOisin A. O'Corragain - Temple UniversityKonika Sharma - Bassett Medical CenterSomchai Prechawat - King Chulalongkorn Memorial HospitalPatompong Ungprasert - Siriraj HospitalKanramon Watthanasuntorn - Bassett Medical CenterPavida Pachariyanon - Texas Tech University Health Sciences CenterWisit Cheungpasitporn - University of Mississippi Medical Center
- Resource Type
- Journal article
- Publication Details
- Advances in medical sciences, Vol.64(2), pp.415-422
- Publisher
- Elsevier
- DOI
- 10.1016/j.advms.2019.07.003
- PMID
- 31521944
- ISSN
- 1896-1126
- eISSN
- 1898-4002
- Number of pages
- 8
- Language
- English
- Date published
- 09/01/2019
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984694743802771
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