Journal article
Incidence of chronic osteomyelitis between 2016 and 2022 in a large, multicenter database in the United States
Journal of bone and joint infection, Vol.10(5), pp.377-384
10/15/2025
DOI: 10.5194/jbji-10-377-2025
PMCID: PMC12598500
PMID: 41221510
Abstract
Introduction: Chronic osteomyelitis (COM) is a serious musculoskeletal infection that affects a patient's quality of life and long-term survival. In this study, we assessed overall, regional, and patient-level characteristics of bacterial COM in a large, multicenter database in the United States. Methods: We used ICD-10 codes to identify incident bacterial COM in the TriNetX database between 1 January 2016 and 31 December 2022. We calculated COM incidence per 1000 adult patients with the associated 95 % confidence intervals. We used the Cochran–Armitage test to assess incidence trends across the study period. Results: A total of 93 324 adult patients were identified. Overall, a steady COM incidence was observed over time, with some indication of lower rates starting in 2020. The incidence was about 2-fold higher in males than females. As expected, lower-extremity COM was most common overall and among males. Although lower-extremity COM and vertebral COM had comparable incidence among females, vertebral COM became slightly more common than lower-extremity COM among females during the study period. Conclusions: To our knowledge, this study provides the largest available, multicenter estimate of COM incidence in the United States. Although the incidence of COM was generally steady over time, a slight reduction was noted during the pandemic (2020 and later). This finding may reflect important differences in ascertainment or competing risks during that period.
Details
- Title: Subtitle
- Incidence of chronic osteomyelitis between 2016 and 2022 in a large, multicenter database in the United States
- Creators
- Rawabi AljadaniHyunkeun ChoMartha L. Carvour
- Resource Type
- Journal article
- Publication Details
- Journal of bone and joint infection, Vol.10(5), pp.377-384
- DOI
- 10.5194/jbji-10-377-2025
- PMID
- 41221510
- PMCID
- PMC12598500
- NLM abbreviation
- J Bone Jt Infect
- ISSN
- 2206-3552
- eISSN
- 2206-3552
- Publisher
- COPERNICUS GESELLSCHAFT MBH
- Number of pages
- 8
- Grant note
- National Institutes of HealthDepartment of Epidemiology at the University of Iowa College of Public Health
The authors wish to thank Ryan Carnahan, Margaret Chorazy, and James Torner from the Department of Epidemiology at the University of Iowa College of Public Health for their feedback, expertise, and support throughout the study.
- Language
- English
- Date published
- 10/15/2025
- Academic Unit
- Infectious Diseases; Epidemiology; Biostatistics; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9985014802702771
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