Journal article
Incidence of neonatal hypertension from a large multicenter study [Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates-AWAKEN]
Pediatric research, Vol.84(2), pp.279-289
08/01/2018
DOI: 10.1038/s41390-018-0018-8
PMID: 29795211
Abstract
BACKGROUND: Hypertension occurs in up to 3% of neonates admitted to the Neonatal Intensive Care Unit (NICU), and is a potentially under-recognized condition. The aim of this study was to examine the incidence of documented and undiagnosed hypertension from the 24-center Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) database, and to assess risk factors for hypertension according to gestational age.
METHODS: Diagnosed hypertension was documented if an infant had a discharge diagnosis of hypertension and/or discharged on antihypertensive medications. Undiagnosed hypertension was defined when infants did not have a diagnosis of hypertension, but >50% of the lowest mean, diastolic and systolic blood pressure recordings were >95th percentile for gestational age.
RESULTS: Of the 2162 neonates enrolled in the study, hypertension was documented in 1.8%. An additional 37% were defined as having undiagnosed hypertension. There was a significant correlation with neonatal hypertension and acute kidney injury (AKI). Additional risk factors for neonatal hypertension were hyperbilirubinaemia, Caucasian race, outborn, vaginal delivery, and congenital heart disease. Protective factors were small for gestational age, multiple gestations, and steroids for fetal maturation.
CONCLUSIONS: Neonatal hypertension may be an under-recognized condition. AKI and other risk factors predispose infants to hypertension.
Details
- Title: Subtitle
- Incidence of neonatal hypertension from a large multicenter study [Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates-AWAKEN]
- Creators
- Emily J. Kraut - Australian National UniversityLouis J. Boohaker - University of AlabamaDavid J. Askenazi - University of AlabamaJeffery Fletcher - Australian National UniversityAlison L. Kent - Australian National UniversityNeonatal Kidney Collaborative (NKC)
- Contributors
- Tarah T Colaizy (Contributor) - University of Iowa, NeonatologyJonathan M Klein (Contributor) - University of Iowa, Neonatology
- Resource Type
- Journal article
- Publication Details
- Pediatric research, Vol.84(2), pp.279-289
- Publisher
- Springer Nature
- DOI
- 10.1038/s41390-018-0018-8
- PMID
- 29795211
- ISSN
- 0031-3998
- eISSN
- 1530-0447
- Number of pages
- 11
- Grant note
- Children's of Alabama Hospital U54TR001356 / University of Iowa Institute for Clinical and Translational Science UL1TR001417 / UAB's Center for Clinical and Translational Sciences (CCTS, NIH grant) UL1TR001449 / Clinical and Translational Science Center (CTSC, NIH grant) Pediatric and Infant Center for Acute Nephrology (PICAN) Cincinnati Children's Hospital Center for Acute Care Nephrology Department of Pediatrics, UAB School of Medicine
- Language
- English
- Date published
- 08/01/2018
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984354047902771
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