Incidence of oral candidiasis and oral hairy leukoplakia in HIV-infected adults in North Carolina

Amit Chattopadhyay; Daniel J Caplan; Gary D Slade; Diane C Shugars; Hsaio-Chuan Tien; Lauren L Patton

doi:10.1016/j.tripleo.2004.06.081

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Journal article

Incidence of oral candidiasis and oral hairy leukoplakia in HIV-infected adults in North Carolina

Amit Chattopadhyay, Daniel J Caplan, Gary D Slade, Diane C Shugars, Hsaio-Chuan Tien and Lauren L Patton

Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, Vol.99(1), pp.39-47

01/2005

DOI: 10.1016/j.tripleo.2004.06.081

PMID: 15599347

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Abstract

To establish incidence rates and risk factors for HIV-associated oral candidiasis (OC), oral hairy leukoplakia (OHL), and any HIV-associated oral diseases (HIV-OD). This prospective, cumulative case-control study followed 283 initially oral disease-free HIV-1-infected men and women for 2 years. Incidence rate ratios (IRR) and incidence proportions for OC, OHL, and HIV-OD were estimated. Multivariable analyses using Poisson regression determined the most parsimonious best-fitting model explaining the outcomes. Incidence rate (per 1000 person-months) was 9.3 for OC, 6.8 for OHL, and 13.5 for HIV-OD. Incidence of OC was associated with low CD4 count (adjusted IRR = 3.0 (95% CI = 1.7, 5.1)), smoking (IRR = 1.9 (1.0, 3.8)) and combination antiretroviral therapy (IRR = 0.3 (0.1, 0.8)). Incidence of OHL was associated with low CD4 count, conditional upon smoking status. Conclusions Low CD4 count and smoking are important risk factors for HIV-associated OC and OHL. Antiretroviral medications are protective for OC but not for OHL.

Multivariate Analysis

Prospective Studies

Follow-Up Studies

HIV Infections - epidemiology

Humans

Risk Factors

Male

CD4 Lymphocyte Count

Candidiasis, Oral - epidemiology

Case-Control Studies

Incidence

Regression Analysis

Leukoplakia, Hairy - epidemiology

Smoking - epidemiology

AIDS-Related Opportunistic Infections - epidemiology

Adolescent

Adult

Anti-HIV Agents - therapeutic use

Female

Poisson Distribution

North Carolina - epidemiology

Details

Title: Subtitle: Incidence of oral candidiasis and oral hairy leukoplakia in HIV-infected adults in North Carolina
Creators: Amit Chattopadhyay - Department of Informatics, School of Dentistry, Temple University, Philadelphia, PA, USA
Daniel J Caplan
Gary D Slade
Diane C Shugars
Hsaio-Chuan Tien
Lauren L Patton
Resource Type: Journal article
Publication Details: Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, Vol.99(1), pp.39-47
Publisher: United States
DOI: 10.1016/j.tripleo.2004.06.081
PMID: 15599347
ISSN: 1079-2104
eISSN: 1528-395X
Grant note: 5T32DE07191 / NIDCR NIH HHS P30-HD27360 / NICHD NIH HHS DE11369 / NIDCR NIH HHS
Language: English
Date published: 01/2005
Academic Unit: Preventive and Community Dentistry
Record Identifier: 9983917688402771

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