Journal article
Incidence of ventricular arrhythmias related to COVID infection and vaccination in patients with Brugada syndrome: Insights from a large Italian multicenter registry based on continuous rhythm monitoring
Journal of cardiovascular electrophysiology, Vol.34(6), pp.1386-1394
06/2023
DOI: 10.1111/jce.15929
PMID: 37194742
Abstract
Brugada syndrome (BrS) has a dynamic ECG pattern that might be revealed by certain conditions such as fever. We evaluated the incidence and management of ventricular arrhythmias (VAs) related to COVID-19 infection and vaccination among BrS patients carriers of an implantable loop recorder (ILR) or implantable cardioverter-defibrillator (ICD) and followed by remote monitoring.
This was a multicenter retrospective study. Patients were carriers of devices with remote monitoring follow-up. We recorded VAs 6 months before COVID-19 infection or vaccination, during infection, at each vaccination, and up to 6-month post-COVID-19 or 1 month after the last vaccination. In ICD carriers, we documented any device intervention.
We included 326 patients, 202 with an ICD and 124 with an ILR. One hundred and nine patients (33.4%) had COVID-19, 55% of whom developed fever. Hospitalization rate due to COVID-19 infection was 2.76%. After infection, we recorded only two ventricular tachycardias (VTs). After the first, second, and third vaccines, the incidence of non-sustained ventricular tachycardia (NSVT) was 1.5%, 2%, and 1%, respectively. The incidence of VT was 1% after the second dose. Six-month post-COVID-19 healing or 1 month after the last vaccine, we documented NSVT in 3.4%, VT in 0.5%, and ventricular fibrillation in 0.5% of patients. Overall, one patient received anti-tachycardia pacing and one a shock. ILR carriers had no VAs. No differences were found in VT before and after infection and before and after each vaccination.
From this large multicenter study conducted in BrS patients, followed by remote monitoring, the overall incidence of sustained VAs after COVID-19 infection and vaccination is relatively low.
Details
- Title: Subtitle
- Incidence of ventricular arrhythmias related to COVID infection and vaccination in patients with Brugada syndrome: Insights from a large Italian multicenter registry based on continuous rhythm monitoring
- Creators
- Michela Casella - Marche Polytechnic UniversitySergio Conti - Department of Electrophysiology, ARNAS Civico - Di Cristina - Benfratelli, Palermo, ItalyPaolo Compagnucci - Marche Polytechnic UniversityValentina Ribatti - Centro Cardiologico MonzinoMaria Lucia Narducci - Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, ItalyLorenzo Marcon - Centro Cardiologico MonzinoFrancesca Massara - Cardiology and Arrhythmology Clinic, University Hospital Ospedali Riuniti Umberto I-Lancisi-Salesi, Ancona, ItalyYari Valeri - Cardiology and Arrhythmology Clinic, University Hospital Ospedali Riuniti Umberto I-Lancisi-Salesi, Ancona, ItalyLuca De Francesco - Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, ItalyAnna Maria Martino - Policlinico CasilinoChiara Ghiglieno - Università degli Studi del Piemonte Orientale “Amedeo Avogadro”Marco Schiavone - Luigi Sacco HospitalCristina Balla - Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, ItalyGabriele Dell'Era - Università degli Studi del Piemonte Orientale “Amedeo Avogadro”Gemma Pelargonio - Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, ItalyGiovanni Battista Forleo - Luigi Sacco HospitalSaverio Iacopino - Maria Cecilia HospitalGiuseppe Sgarito - Department of Electrophysiology, ARNAS Civico - Di Cristina - Benfratelli, Palermo, ItalyLeonardo Calò - Policlinico CasilinoClaudio Tondo - University of MilanAntonio Dello Russo - Marche Polytechnic UniversityGiuseppe Patti - Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
- Resource Type
- Journal article
- Publication Details
- Journal of cardiovascular electrophysiology, Vol.34(6), pp.1386-1394
- Publisher
- Wiley
- DOI
- 10.1111/jce.15929
- PMID
- 37194742
- ISSN
- 1045-3873
- eISSN
- 1540-8167
- Language
- English
- Date published
- 06/2023
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984822989502771
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