Journal article
Incident infection following acute kidney injury with recovery to baseline creatinine: A propensity score matched analysis
PloS one, Vol.14(6), pp.e0217935-e0217935
06/24/2019
DOI: 10.1371/journal.pone.0217935
PMCID: PMC6590794
PMID: 31233518
Abstract
Background
Severe acute kidney injury (AKI) is associated with subsequent infection. Whether AKI followed by a return to baseline creatinine is associated with incident infection is unknown.
Objective
We hypothesized that risk of both short and long term infection would be higher among patients with AKI and return to baseline creatinine than in propensity score matched peers without AKI in the year following a non-infectious hospital admission.
Design
Retrospective, propensity score matched cohort study.
Participants
We identified 494 patients who were hospitalized between January 1, 1999 and December 31, 2009 and had AKI followed by return to baseline creatinine. These were propensity score matched to controls without AKI.
Main Measures
The predictor variable was AKI defined by International Classification of Diseases, Ninth Revision (ICD-9) codes and by the Kidney Disease Improving Global Outcomes definition, with return to baseline creatinine defined as a decrease in serum creatinine level to within 10% of the baseline value within 7 days of hospital discharge. The outcome variable was incident infection defined by ICD-9 code within 1 year of hospital discharge.
Results
AKI followed by return to baseline creatinine was associated with a 4.5-fold increased odds ratio for infection (odds ratio 4.53 [95% CI, 2.43-8.45]; p<0.0001) within 30 days following discharge. The association between AKI and subsequent infection remained significant at 31-60 days and 91 to 365 days but not during 61-90 days following discharge.
Conclusion
Among patients from an integrated health care delivery system, non-infectious AKI followed by return to baseline creatinine was associated with an increased odds ratio for infection in the year following discharge.
Details
- Title: Subtitle
- Incident infection following acute kidney injury with recovery to baseline creatinine: A propensity score matched analysis
- Creators
- Benjamin R. Griffin - University of Colorado DenverZhiying You - University of Colorado Anschutz Medical CampusJohn Holmen - Intermountain HealthcareMegan SooHoo - Children's Hospital ColoradoKatja M. Gist - Children's Hospital ColoradoJames F. Colbert - University of Colorado Anschutz Medical CampusMichel Chonchol - University of Colorado Anschutz Medical CampusSarah Faubel - University of Colorado Anschutz Medical CampusAnna Jovanovich - University of Colorado Anschutz Medical Campus
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.14(6), pp.e0217935-e0217935
- DOI
- 10.1371/journal.pone.0217935
- PMID
- 31233518
- PMCID
- PMC6590794
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Publisher
- Public Library Science
- Number of pages
- 13
- Grant note
- 5T32DK007135-43 / NIH T32 program; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Intermountain Healthcare System CDA 5IK2CX001030-03 / Veterans Administration; US Department of Veterans Affairs T32DK007135 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) K08AG061144 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Language
- English
- Date published
- 06/24/2019
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984359825102771
Metrics
12 Record Views