Journal article
Incidentally Detected Celiac Disease with Splenomegaly on 18F FDG PET/CT: A Potential Lymphoma Mimic
Asia oceania journal of nuclear medicine and biology, Vol.9(1), pp.51-55
01/01/2021
DOI: 10.22038/AOJNMB.2020.49000.1333
PMCID: PMC7701229
PMID: 33392350
Abstract
Celiac disease is an immune-mediated disorder triggered by hypersensitivity to gluten occurring in genetically susceptible individuals. A high-index of suspicion is needed for diagnosis as patients can be asymptomatic or present with atypical symptoms or extra-intestinal manifestations. Typical
18
F-Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET)/Computed Tomography (CT) gastrointestinal manifestations of celiac disease include increased multifocal or diffuse jejunal and ileal uptake; focal duodenal uptake is less common. Splenomegaly with increased splenic FDG uptake is also uncommon in celiac disease in the absence of portal hypertension; small-sized spleen and functional hyposplenism are more typical. We report a case of celiac disease diagnosed after PET/CT showed FDG uptake in the duodenum and enlarged spleen. Follow-up after gluten-free diet showed complete metabolic resolution and regression of splenomegaly. The combination of focal bowel and splenic uptake is unusual in celiac disease and may be mistaken for a lymphoproliferative disorder. Awareness of this entity may avoid misdiagnosis and guide appropriate management.
Details
- Title: Subtitle
- Incidentally Detected Celiac Disease with Splenomegaly on 18F FDG PET/CT: A Potential Lymphoma Mimic
- Creators
- Ananya Panda - Mayo ClinicMichael R. McCarthy - Mayo ClinicJoseph A. Murray - Mayo ClinicRosalind F. Sharain - Mayo ClinicMin Shi - Mayo ClinicAyse Tuba Kendi - Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- Asia oceania journal of nuclear medicine and biology, Vol.9(1), pp.51-55
- Publisher
- Mashhad University of Medical Sciences
- DOI
- 10.22038/AOJNMB.2020.49000.1333
- PMID
- 33392350
- PMCID
- PMC7701229
- ISSN
- 2322-5718
- eISSN
- 2322-5726
- Language
- English
- Date published
- 01/01/2021
- Academic Unit
- Radiology
- Record Identifier
- 9984697721102771
Metrics
3 Record Views