Journal article
Inclusion body myositis and sarcoid myopathy: coincidental occurrence or associated diseases
Neuromuscular disorders : NMD, Vol.25(4), pp.297-300
04/2015
DOI: 10.1016/j.nmd.2014.12.005
PMID: 25599912
Abstract
Inclusion body myositis (IBM) is a slowly progressive inflammatory myopathy characterized by selective weakness of finger flexors and quadriceps muscles commonly refractory to treatment. Another chronic inflammatory disorder, sarcoidosis, commonly involves muscle. The comorbidity of inclusion body myositis and sarcoid myopathy is rare. We describe clinical and muscle biopsy findings of a patient with sarcoidosis and inclusion body myositis. A 66-year-old man presented with a 6-year history of progressive, asymmetrical and selective weakness of the quadriceps, biceps and finger flexor muscles; he had a remote history of pulmonary sarcoidosis. A quadriceps muscle biopsy revealed a chronic inflammatory myopathy with ubiquitinated inclusion bodies, rimmed vacuoles, expression of major histocompatibility complex class I, numerous COX-negative fibers and TDP-43 cytoplasmic aggregates (features of IBM) and multiple non-necrotizing granulomata (feature of sarcoidosis). Clinical and histopathologic features of the current illness suggested the patient had sarcoidosis with inclusion body myositis overlap. This patient may represent the coincidental occurrence of both idiopathic inflammatory disorders. Alternatively, sarcoidoisis may promote the development of inclusion body myositis by a similar immune-mediated pathophysiologic process.
Details
- Title: Subtitle
- Inclusion body myositis and sarcoid myopathy: coincidental occurrence or associated diseases
- Creators
- Oranee Sanmaneechai - Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa; Division of Neurology, Department of Pediatrics, Siriraj Hosptial, Mahidol University, Bangkok, Thailand. Electronic address: oranee141@gmail.comAndrea Swenson - Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IowaAlicia K Gerke - Department of Internal Medicine, Pulmonary, Critical Care and Occupational Medicine, University of Iowa Hospitals and Clinics, Iowa City, IowaSteven A Moore - Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IowaMichael E Shy - Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Neuromuscular disorders : NMD, Vol.25(4), pp.297-300
- Publisher
- England
- DOI
- 10.1016/j.nmd.2014.12.005
- PMID
- 25599912
- ISSN
- 0960-8966
- eISSN
- 1873-2364
- Grant note
- P30 ES005605 / NIEHS NIH HHS
- Language
- English
- Date published
- 04/2015
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Stead Family Department of Pediatrics; Pathology; Iowa Neuroscience Institute; Internal Medicine
- Record Identifier
- 9984020602902771
Metrics
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