Journal article
Incomplete Vitreomacular Traction Release Using Intravitreal Ocriplasmin
Case Reports in Ophthalmology, Vol.5(3), pp.455-462
12/12/2014
DOI: 10.1159/000370024
PMCID: PMC4296250
PMID: 25606039
Abstract
Purpose: To report the clinical course of our first 7 consecutive patients treated with intravitreal ocriplasmin (Jetrea®). Methods: Retrospective case series of the first 7 patients treated with ocriplasmin between January and December 2013 at an academic tertiary care center. Results: The average age was 78.4 years (range: 63-92). Five patients were pseudophakic and 2 patients were phakic in the injected eye. The median baseline visual acuity (VA) was 20/60 (range: 20/25 to 20/200). The median 1-month postinjection VA was 20/70, with a mean loss of 2 lines of VA among all patients. None of the patients had complete resolution of their vitreomacular traction or macular hole at 1 month of follow-up. Three patients had subsequent pars plana vitrectomy and membrane peeling surgery. The mean follow-up period for those who did not undergo vitrectomy was 9 months (range: 1-13). One patient with known ocular hypertension had an increase in intraocular pressure requiring topical pressure-lowering eyedrops. There were no cases of postinjection uveitis, endophthalmitis, retinal tears, or retinal detachment. Conclusions: While ocriplasmin may be a viable pharmacological agent for vitreolysis, we present a series of patients that all had incomplete resolution of vitreomacular traction with and without full-thickness macular hole. There was an associated reduction in VA after ocriplasmin treatment at 1 month of follow-up. Careful analysis of the vitreoretinal interface and comorbid eye conditions is required to optimize outcome success with ocriplasmin.
Details
- Title: Subtitle
- Incomplete Vitreomacular Traction Release Using Intravitreal Ocriplasmin
- Creators
- Eric K ChinDavid R.P AlmeidaElliott H SohnH. Culver BoldtVinit B MahajanKaren M GehrsStephen R RussellJames C Folk
- Resource Type
- Journal article
- Publication Details
- Case Reports in Ophthalmology, Vol.5(3), pp.455-462
- DOI
- 10.1159/000370024
- PMID
- 25606039
- PMCID
- PMC4296250
- NLM abbreviation
- Case Rep Ophthalmol
- ISSN
- 1663-2699
- eISSN
- 1663-2699
- Publisher
- Basel, Switzerland
- Number of pages
- 8
- Language
- English
- Date published
- 12/12/2014
- Academic Unit
- Stead Family Department of Pediatrics; Ophthalmology and Visual Sciences
- Record Identifier
- 9983980079102771
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