Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance

Martina Dvorakova; Israt Jahan; Iva Macova; Tetyana Chumak; Romana Bohuslavova; Josef Syka; Bernd Fritzsch; Gabriela Pavlinkova

doi:10.1038/srep38253

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Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance

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Peer reviewed

Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance

Martina Dvorakova, Israt Jahan, Iva Macova, Tetyana Chumak, Romana Bohuslavova, Josef Syka, Bernd Fritzsch and Gabriela Pavlinkova

Scientific reports, Vol.6(1), pp.38253-38253

12/05/2016

DOI: 10.1038/srep38253

PMCID: PMC5137136

PMID: 27917898

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Abstract

The role of Sox2 in neurosensory development is not yet fully understood. Using mice with conditional Islet1-cre mediated deletion of Sox2, we explored the function of Sox2 in neurosensory development in a model with limited cell type diversification, the inner ear. In Sox2 conditional mutants, neurons initially appear to form normally, whereas late- differentiating neurons of the cochlear apex never form. Variable numbers of hair cells differentiate in the utricle, saccule, and cochlear base but sensory epithelium formation is completely absent in the apex and all three cristae of the semicircular canal ampullae. Hair cells differentiate only in sensory epithelia known or proposed to have a lineage relationship of neurons and hair cells. All initially formed neurons lacking hair cell targets die by apoptosis days after they project toward non-existing epithelia. Therefore, late neuronal development depends directly on Sox2 for differentiation and on the survival of hair cells, possibly derived from common neurosensory precursors.

Hair Cells, Auditory - cytology

Saccule and Utricle - embryology

Hair Cells, Auditory - metabolism

Animals

SOXB1 Transcription Factors - genetics

Neurogenesis - physiology

Gene Deletion

Mice, Transgenic

Mice

Saccule and Utricle - cytology

SOXB1 Transcription Factors - metabolism

Details

Title: Subtitle: Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance
Creators: Martina Dvorakova - Faculty of Science, Charles University, Prague, Czechia
Israt Jahan - Department of Biology, University of Iowa, Iowa City, IA, USA
Iva Macova - Faculty of Science, Charles University, Prague, Czechia
Tetyana Chumak - Institute of Experimental Medicine CAS, Prague, Czechia
Romana Bohuslavova - Institute of Biotechnology CAS, Prague, Czechia
Josef Syka - Institute of Experimental Medicine CAS, Prague, Czechia
Bernd Fritzsch - Department of Biology, University of Iowa, Iowa City, IA, USA
Gabriela Pavlinkova - Institute of Biotechnology CAS, Prague, Czechia
Resource Type: Journal article
Publication Details: Scientific reports, Vol.6(1), pp.38253-38253
DOI: 10.1038/srep38253
PMID: 27917898
PMCID: PMC5137136
NLM abbreviation: Sci Rep
ISSN: 2045-2322
eISSN: 2045-2322
Publisher: England
Grant note: R03 DC013655 / NIDCD NIH HHS P30 DC010362 / NIDCD NIH HHS
Language: English
Date published: 12/05/2016
Academic Unit: Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
Record Identifier: 9984070864902771

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