Journal article
Increase in serum pregnancy-associated plasma protein-A is correlated with increase in cardiovascular risk factors in adult patients with growth hormone deficiency
Endocrine, Vol.42(2), pp.375-381
10/01/2012
DOI: 10.1007/s12020-012-9697-9
PMID: 22644835
Abstract
Adult Growth Hormone Deficiency (AGHD) is correlated to many adverse effects on metabolism and increased cardiovascular risk. Pregnancy-associated plasma protein-A (PAPP-A) is a protease that promotes IGF-I availability in vascular tissues in recent study, and PAPP-A levels have been proposed as an early predictor of cardiac events. The aim of our study was to compare PAPP-A levels in AGHD patients with that of healthy adult subjects to determine if there is a relationship between serum PAPP-A and glucose and lipid metabolism. Twenty AGHD patients and 20 healthy, age-matched and weight-matched persons were chosen for the study. Their weight, height, blood pressure, body mass index (BMI), body fat percentage, waist and hip circumference, and waist-hips ratio were assessed. An oral glucose tolerance test was performed and venous blood was collected from the each patient's cubital vein for biochemical analysis. Serum PAPP-A level in AGHD patients was significantly higher than that of the control group [(7.62 +/- A 1.62 vs. 6.54 +/- A 1.31) p < 0.05], and PAPP-A was positively correlated to age, BMI, waist circumference and so on. After adjusting for the waist circumference, waist-hip ratio, 2 h postprandial blood glucose, triglycerides, the serum PAPP-A in AGHD patients was positively correlated to the BMI (r = 0.728, p < 0.05) and fasting insulin (r = 0.433, p < 0.05). In a multiple step-wise regression analysis, BMI, 2 h postprandial glucose, fasting insulin, HOMA-IR were independently associated with serum PAPP-A in AGHD patients. The increase in serum PAPP-A levels is associated with abnormal glucose metabolism and increased risk of atherosclerosis in AGHD patients.
Details
- Title: Subtitle
- Increase in serum pregnancy-associated plasma protein-A is correlated with increase in cardiovascular risk factors in adult patients with growth hormone deficiency
- Creators
- Linman Li - Chongqing Medical UniversityWei Ren - Chongqing Medical UniversityJinchao Li - Chongqing Medical UniversityJingjing Liu - Chongqing Medical UniversityLingli Wang - Chongqing Medical UniversityXiaoya Zheng - Chongqing Medical UniversityDezhen Liu - Chongqing Medical UniversitySufang Li - Chongqing Medical UniversityRhonda Souvenir - Loma Linda UniversityJiping Tang - Loma Linda University
- Resource Type
- Journal article
- Publication Details
- Endocrine, Vol.42(2), pp.375-381
- Publisher
- Humana Press Inc
- DOI
- 10.1007/s12020-012-9697-9
- PMID
- 22644835
- ISSN
- 1355-008X
- eISSN
- 1559-0100
- Number of pages
- 7
- Grant note
- 2010-2-109 / Medical science fund of health 344bureau of Chongqing
- Language
- English
- Date published
- 10/01/2012
- Academic Unit
- Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984359803502771
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