Increased Frequency of First-Episode Poststroke Depression After Discontinuation of Escitalopram

Katsunaka Mikami; Ricardo E Jorge; David J Moser; Stephan Arndt; Mijin Jang; Ana Solodkin; Steven L Small; Pasquale Fonzetti; Mark T Hegel; Robert G Robinson

doi:10.1161/STROKEAHA.111.626507

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Increased Frequency of First-Episode Poststroke Depression After Discontinuation of Escitalopram

Journal article

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Increased Frequency of First-Episode Poststroke Depression After Discontinuation of Escitalopram

Katsunaka Mikami, Ricardo E Jorge, David J Moser, Stephan Arndt, Mijin Jang, Ana Solodkin, Steven L Small, Pasquale Fonzetti, Mark T Hegel and Robert G Robinson

Stroke (1970), Vol.42(11), pp.3281-3283

11/2011

DOI: 10.1161/STROKEAHA.111.626507

PMID: 21868736

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Abstract

Background and purpose: The purpose of this study was to compare escitalopram, problem-solving therapy, and placebo to prevent poststroke depression during 6 months after discontinuation of treatment. Methods: We examined for depression 33 patients assigned to placebo, 34 to escitalopram, and 41 to problem-solving therapy. Results: After controlling for age, gender, prior mood disorder, and severity of stroke, new-onset major depression and Hamilton Depression scores were significantly higher 6 months after escitalopram was discontinued compared with the problem-solving therapy or placebo groups. Conclusions: Discontinuation of escitalopram may increase poststroke depressive symptoms.

Details

Title: Subtitle: Increased Frequency of First-Episode Poststroke Depression After Discontinuation of Escitalopram
Creators: Katsunaka Mikami - From the Department of Psychiatry (K.M., R.E.J., D.J.M., S.A., M.J., R.G.R.), Carver College of Medicine, University of Iowa, Iowa City, IA; the Departments of Anatomy & Neurobiology (A.S.) and Neurology (S.L.S.), University of California–Irvine, Irvine, CA; Cornell University (P.F.), Weill Medical College, and the Memory Evaluation and Treatment Service, The Burke Rehabilitation Hospital, White Plains, NY; the Departments of Psychiatry & Community and Family Medicine (M.T.H.), Dartmouth
Ricardo E Jorge - From the Department of Psychiatry (K.M., R.E.J., D.J.M., S.A., M.J., R.G.R.), Carver College of Medicine, University of Iowa, Iowa City, IA; the Departments of Anatomy & Neurobiology (A.S.) and Neurology (S.L.S.), University of California–Irvine, Irvine, CA; Cornell University (P.F.), Weill Medical College, and the Memory Evaluation and Treatment Service, The Burke Rehabilitation Hospital, White Plains, NY; the Departments of Psychiatry & Community and Family Medicine (M.T.H.), Dartmouth
David J Moser - From the Department of Psychiatry (K.M., R.E.J., D.J.M., S.A., M.J., R.G.R.), Carver College of Medicine, University of Iowa, Iowa City, IA; the Departments of Anatomy & Neurobiology (A.S.) and Neurology (S.L.S.), University of California–Irvine, Irvine, CA; Cornell University (P.F.), Weill Medical College, and the Memory Evaluation and Treatment Service, The Burke Rehabilitation Hospital, White Plains, NY; the Departments of Psychiatry & Community and Family Medicine (M.T.H.), Dartmouth
Stephan Arndt - From the Department of Psychiatry (K.M., R.E.J., D.J.M., S.A., M.J., R.G.R.), Carver College of Medicine, University of Iowa, Iowa City, IA; the Departments of Anatomy & Neurobiology (A.S.) and Neurology (S.L.S.), University of California–Irvine, Irvine, CA; Cornell University (P.F.), Weill Medical College, and the Memory Evaluation and Treatment Service, The Burke Rehabilitation Hospital, White Plains, NY; the Departments of Psychiatry & Community and Family Medicine (M.T.H.), Dartmouth
Mijin Jang - From the Department of Psychiatry (K.M., R.E.J., D.J.M., S.A., M.J., R.G.R.), Carver College of Medicine, University of Iowa, Iowa City, IA; the Departments of Anatomy & Neurobiology (A.S.) and Neurology (S.L.S.), University of California–Irvine, Irvine, CA; Cornell University (P.F.), Weill Medical College, and the Memory Evaluation and Treatment Service, The Burke Rehabilitation Hospital, White Plains, NY; the Departments of Psychiatry & Community and Family Medicine (M.T.H.), Dartmouth
Ana Solodkin - From the Department of Psychiatry (K.M., R.E.J., D.J.M., S.A., M.J., R.G.R.), Carver College of Medicine, University of Iowa, Iowa City, IA; the Departments of Anatomy & Neurobiology (A.S.) and Neurology (S.L.S.), University of California–Irvine, Irvine, CA; Cornell University (P.F.), Weill Medical College, and the Memory Evaluation and Treatment Service, The Burke Rehabilitation Hospital, White Plains, NY; the Departments of Psychiatry & Community and Family Medicine (M.T.H.), Dartmouth
Steven L Small - From the Department of Psychiatry (K.M., R.E.J., D.J.M., S.A., M.J., R.G.R.), Carver College of Medicine, University of Iowa, Iowa City, IA; the Departments of Anatomy & Neurobiology (A.S.) and Neurology (S.L.S.), University of California–Irvine, Irvine, CA; Cornell University (P.F.), Weill Medical College, and the Memory Evaluation and Treatment Service, The Burke Rehabilitation Hospital, White Plains, NY; the Departments of Psychiatry & Community and Family Medicine (M.T.H.), Dartmouth
Pasquale Fonzetti - From the Department of Psychiatry (K.M., R.E.J., D.J.M., S.A., M.J., R.G.R.), Carver College of Medicine, University of Iowa, Iowa City, IA; the Departments of Anatomy & Neurobiology (A.S.) and Neurology (S.L.S.), University of California–Irvine, Irvine, CA; Cornell University (P.F.), Weill Medical College, and the Memory Evaluation and Treatment Service, The Burke Rehabilitation Hospital, White Plains, NY; the Departments of Psychiatry & Community and Family Medicine (M.T.H.), Dartmouth
Mark T Hegel - From the Department of Psychiatry (K.M., R.E.J., D.J.M., S.A., M.J., R.G.R.), Carver College of Medicine, University of Iowa, Iowa City, IA; the Departments of Anatomy & Neurobiology (A.S.) and Neurology (S.L.S.), University of California–Irvine, Irvine, CA; Cornell University (P.F.), Weill Medical College, and the Memory Evaluation and Treatment Service, The Burke Rehabilitation Hospital, White Plains, NY; the Departments of Psychiatry & Community and Family Medicine (M.T.H.), Dartmouth
Robert G Robinson - From the Department of Psychiatry (K.M., R.E.J., D.J.M., S.A., M.J., R.G.R.), Carver College of Medicine, University of Iowa, Iowa City, IA; the Departments of Anatomy & Neurobiology (A.S.) and Neurology (S.L.S.), University of California–Irvine, Irvine, CA; Cornell University (P.F.), Weill Medical College, and the Memory Evaluation and Treatment Service, The Burke Rehabilitation Hospital, White Plains, NY; the Departments of Psychiatry & Community and Family Medicine (M.T.H.), Dartmouth
Resource Type: Journal article
Publication Details: Stroke (1970), Vol.42(11), pp.3281-3283
DOI: 10.1161/STROKEAHA.111.626507
PMID: 21868736
NLM abbreviation: Stroke
ISSN: 0039-2499
eISSN: 1524-4628
Language: English
Date published: 11/2011
Academic Unit: Psychiatry; Biostatistics; Nursing; Injury Prevention Research Center; Medicine Administration
Record Identifier: 9984003940602771

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