Journal article
Increased Hydrogen Peroxide in the Expired Breath of Patients with Acute Hypoxemic Respiratory Failure
Chest, Vol.96(3), pp.606-612
09/1989
DOI: 10.1378/chest.96.3.606
PMID: 2766820
Abstract
Acute hypoxemic respiratory failure (AHRF) can result from diverse lung insults. Toxic oxygen metabolites have been implicated in this clinical condition and in animal models of pulmonary edema. Hydrogen peroxide (H2O2), an oxygen metabolite, mediates tissue injury. We measured H2O2 levels by a spectrophotometric technique in the breath condensate of 68 mechanically ventilated patients; 13 patients with normal lungs undergoing elective surgery had no such detectable levels of H2O2. Fifty-five patients in the ICU meeting criteria for the adult respiratory distress syndrome (ARDS) had a higher concentration of H2O2 in the expired breath condensate than ICU patients without pulmonary infiltrates (2.34 ± 1.15 vs 0.99 ±0.72 μmol/L, p<0.005). This marker had a sensitivity of S7.5 percent and a specificity of 81.3 percent in separating the two patient populations. Patients with AHRF and focal pulmonary infiltrates who did not meet criteria for ARDS also had higher concentrations of H2O2 (2.45 ±1.55 μmol/L) than patients without pulmonary infiltrates (p<0.001). No difference was observed between the expired H2O2 concentrations of patients with ARDS or patients with focal pulmonary infiltrates. Patients with brain injury or sepsis tended to have higher levels of H2O2 regardless of lung pathology. Increased levels of H2O2 are detected in the expired breath of ICU patients with focal lung infiltrates and in ARDS patients, which is consistent with the hypothesis that oxygen metabolites participate in the pathogenesis of ARDS and other forms of AHRF.
Details
- Title: Subtitle
- Increased Hydrogen Peroxide in the Expired Breath of Patients with Acute Hypoxemic Respiratory Failure
- Creators
- J. Iasha Sznajder - From the Section of Pulmonary and Critical Care Medicine, Michael Reese Hospital and Medical Center, and the University of Chicago Medical Center, ChicagoAna Fraiman - From the Section of Pulmonary and Critical Care Medicine, Michael Reese Hospital and Medical Center, and the University of Chicago Medical Center, ChicagoJesse B Hall - From the Section of Pulmonary and Critical Care Medicine, Michael Reese Hospital and Medical Center, and the University of Chicago Medical Center, ChicagoWilliam Sanders - From the Section of Pulmonary and Critical Care Medicine, Michael Reese Hospital and Medical Center, and the University of Chicago Medical Center, ChicagoGregory Schmidt - From the Section of Pulmonary and Critical Care Medicine, Michael Reese Hospital and Medical Center, and the University of Chicago Medical Center, ChicagoGregory Crawford - University of Chicago Medical CenterAvi Nahum - From the Section of Pulmonary and Critical Care Medicine, Michael Reese Hospital and Medical Center, and the University of Chicago Medical Center, ChicagoPhillip Factor - From the Section of Pulmonary and Critical Care Medicine, Michael Reese Hospital and Medical Center, and the University of Chicago Medical Center, ChicagoLawrence D.H Wood - From the Section of Pulmonary and Critical Care Medicine, Michael Reese Hospital and Medical Center, and the University of Chicago Medical Center, Chicago
- Resource Type
- Journal article
- Publication Details
- Chest, Vol.96(3), pp.606-612
- Publisher
- Elsevier Inc
- DOI
- 10.1378/chest.96.3.606
- PMID
- 2766820
- ISSN
- 0012-3692
- eISSN
- 1931-3543
- Language
- English
- Date published
- 09/1989
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984094491902771
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