Journal article
Increased Incidence of Surgical Intervention for Otitis Media With Effusion Among Patients With Type 2 Inflammatory Diseases
The journal of allergy and clinical immunology in practice (Cambridge, MA), Vol.13(3), pp.658-669
03/2025
DOI: 10.1016/j.jaip.2024.12.014
PMID: 39808094
Abstract
Otitis media with effusion (OME) is associated with comorbidities such as allergic rhinitis, gastroesophageal reflux disease, asthma, and more. Many of these comorbidities can be caused by type 2 inflammation (T2I). This study aims to determine the risk of undergoing OME surgery in patients with and without T2I disease.
To determine whether T2I disease is associated with an increased incidence of OME surgery.
This retrospective, matched-cohort study involved the retrospective recruitment of patients with T2I disease (n = 31,603) and non-T2I disease (n = 31,603) from 2010 to 2019, using the Taiwan National Health Insurance Research Database. Statistical analyses were performed using t tests, Cox proportional regression models, Kaplan-Meier estimators, and log-rank tests.
Among patients with OME, those with T2I disease had a greater risk of undergoing OME surgery, with an adjusted hazard ratio of 9.84 (95% confidence interval [CI], 8.90-10.88), than those without T2I disease. The adjusted relative risk for the number of OME surgeries in patients with T2I disease was 11.14 (95% CI, 10.30-12.05). Kaplan-Meier analysis showed consistently higher cumulative incidence curves in patients with T2I disease throughout the follow-up period (log-rank test: P < .001).
OME patients with T2I disease had a significantly higher incidence of undergoing surgery due to failed conservative treatment, indicating that T2I may play an important role in middle ear disorders. Further research on this topic should be considered significant and worthy of investigation.
Details
- Title: Subtitle
- Increased Incidence of Surgical Intervention for Otitis Media With Effusion Among Patients With Type 2 Inflammatory Diseases
- Creators
- Yen-Che Wang - China Medical UniversityYou-Cheng Yu - China Medical UniversityShih-Huan Chen - China Medical UniversityJen-Chih Lee - China Medical UniversityTang-Chuan Wang - China Medical UniversityHeng-Jun Lin - China Medical UniversityCheng-Li Lin - China Medical UniversityChun-Hsu Yao - China Medical UniversityTzu-Liang Chen - China Medical UniversityFuu-Jen Tsai - China Medical UniversityDer-Yang Cho - China Medical UniversityRichard S Tyler - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The journal of allergy and clinical immunology in practice (Cambridge, MA), Vol.13(3), pp.658-669
- DOI
- 10.1016/j.jaip.2024.12.014
- PMID
- 39808094
- NLM abbreviation
- J Allergy Clin Immunol Pract
- ISSN
- 2213-2198
- eISSN
- 2213-2201
- Publisher
- ELSEVIER
- Grant note
- China Medical University Hsinchu Hospital in TaiwanChina Medical University in Taiwan: CMUHCH-CMU-113-007, CMUHCH-DMR-113-012, CMUHCH-DMR-112-031, CMU112-SR-74 National Science and Technology Council in Taiwan: 112-2813-C-039-083-B
This work was supported by grants from the China Medical University Hsinchu Hospital in Taiwan and China Medical University in Taiwan (CMUHCH-CMU-113-007, CMUHCH-DMR-113-012, CMUHCH-DMR-112-031, and CMU112-SR-74) . In addition, this study was supported in part by the National Science and Technology Council in Taiwan (112-2813-C-039-083-B) .r We would like to thank Professor Richard J. Salvi, Professor at the Center for Hearing and Deafness, University at Buffalo, Buffalo, NY, for his insightful comments and suggestions thatr improved the manuscript. We also thank these grants from the China Medical University Hsinchu Hospital in Taiwan and China Medical University in Taiwan (CMUHCH-CMU-113-007 and CMUHCH-DMR-113-012 and CMUHCH-DMR-112-031 and CMU112-SR-74) . Additionally, this study was supported in part by The National Science and Technology Council in Taiwan (112-2813-C-039-083-B) .
- Language
- English
- Electronic publication date
- 01/14/2025
- Date published
- 03/2025
- Academic Unit
- Communication Sciences and Disorders; Otolaryngology; University College Courses
- Record Identifier
- 9984774237702771
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