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Increased Incidence of Vestibular Disorders in Patients With SARS-CoV-2
Journal article   Open access   Peer reviewed

Increased Incidence of Vestibular Disorders in Patients With SARS-CoV-2

Lawrance Lee, Evan French, Daniel H Coelho, Nauman F Manzoor, National COVID Cohort Collaborative (N3C) consortium, Adam B Wilcox, Adam M Lee, Alexis Graves, Alfred Anzalone, Amin Manna, …
Otology & neurotology open, Vol.4(2), e051
06/2024
DOI: 10.1097/ONO.0000000000000051
PMCID: PMC11195920
PMID: 38919767
url
https://doi.org/10.1097/ONO.0000000000000051View
Published (Version of record) Open Access

Abstract

Determine the incidence of vestibular disorders in patients with SARS-CoV-2 compared to the control population. Retrospective. Clinical data in the National COVID Cohort Collaborative database (N3C). Deidentified patient data from the National COVID Cohort Collaborative database (N3C) were queried based on variant peak prevalence (untyped, alpha, delta, omicron 21K, and omicron 23A) from covariants.org to retrospectively analyze the incidence of vestibular disorders in patients with SARS-CoV-2 compared to control population, consisting of patients without documented evidence of COVID infection during the same period. Patients testing positive for COVID-19 were significantly more likely to have a vestibular disorder compared to the control population. Compared to control patients, the odds ratio of vestibular disorders was significantly elevated in patients with untyped (odds ratio [OR], 2.39; confidence intervals [CI], 2.29-2.50; < 0.001), alpha (OR, 3.63; CI, 3.48-3.78; < 0.001), delta (OR, 3.03; CI, 2.94-3.12; < 0.001), omicron 21K variant (OR, 2.97; CI, 2.90-3.04; < 0.001), and omicron 23A variant (OR, 8.80; CI, 8.35-9.27; < 0.001). The incidence of vestibular disorders differed between COVID-19 variants and was significantly elevated in COVID-19-positive patients compared to the control population. These findings have implications for patient counseling and further research is needed to discern the long-term effects of these findings.
COVID-19 Dizziness SARS-CoV-2 Vestibular disorder

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