Increased Lung Immune Metabolic Activity in COVID-19 Survivors

Rosana Souza Rodrigues; Gabriel Motta Ribeiro; Miriam Menna Barreto; Walter Araujo Zin; Júlia De Toledo-Mendes; Philippe Alcantara G. Martins; Sergio Altino De Almeida; Rodrigo Basílio; Remy Martins-Gonçalves; Eugênio Damaceno Hottz; Patricia T. Bozza; Fernando A. Bozza; Alysson Roncally Silva Carvalho; Paulo Henrique Rosado-De-Castro

doi:10.1097/RLU.0000000000004376

Back

Increased Lung Immune Metabolic Activity in COVID-19 Survivors

Journal article

Open access

Peer reviewed

Increased Lung Immune Metabolic Activity in COVID-19 Survivors

Rosana Souza Rodrigues, Gabriel Motta Ribeiro, Miriam Menna Barreto, Walter Araujo Zin, Júlia De Toledo-Mendes, Philippe Alcantara G. Martins, Sergio Altino De Almeida, Rodrigo Basílio, Remy Martins-Gonçalves, Eugênio Damaceno Hottz, …

Clinical nuclear medicine, Vol.47(12), pp.1019-1025

12/01/2022

DOI: 10.1097/RLU.0000000000004376

PMCID: PMC9653065

PMID: 36026599

Files and links (1)

url

https://www.arca.fiocruz.br/handle/icict/55889View

Open Access

Abstract

Purpose We quantified lung glycolytic metabolic activity, clinical symptoms and inflammation, coagulation, and endothelial activation biomarkers in 2019 coronavirus disease (COVID-19) pneumonia survivors. Methods Adults previously hospitalized with moderate to severe COVID-19 pneumonia were prospectively included. Subjects filled out a questionnaire on clinical consequences, underwent chest CT and 18F-FDG PET/CT, and provided blood samples on the same day. Forty-five volunteers served as control subjects. Analysis of CT images and quantitative voxel-based analysis of PET/CT images were performed for both groups. 18F-FDG uptake in the whole-lung volume and in high- and low-attenuation areas was calculated and normalized to liver values. Quantification of plasma markers of inflammation (interleukin 6), d-dimer, and endothelial cell activation (angiopoietins 1 and 2, vascular cell adhesion molecule 1, and intercellular adhesion molecule 1) was also performed. Results We enrolled 53 COVID-19 survivors (62.3% were male; median age, 50 years). All survivors reported at least 1 persistent symptom, and 41.5% reported more than 6 symptoms. The mean lung density was greater in survivors than in control subjects, and more metabolic activity was observed in normal and dense lung areas, even months after symptom onset. Plasma proinflammatory, coagulation, and endothelial activation biomarker concentrations were also significantly higher in survivors. Conclusion We observed more metabolic activity in areas of high and normal lung attenuation several months after moderate to severe COVID-19 pneumonia. In addition, plasma markers of thromboinflammation and endothelial activation persisted. These findings may have implications for our understanding of the in vivo pathogenesis and long-lasting effects of COVID-19 pneumonia.

COVID-19 pneumonia

endothelial cell activation

immunometabolism

long COVID

PET/CT

pulmonary inflammation

Details

Title: Subtitle: Increased Lung Immune Metabolic Activity in COVID-19 Survivors
Creators: Rosana Souza Rodrigues - D’Or Institute for Research and Education
Gabriel Motta Ribeiro - Laboratory of Pulmonary Engineering, Biomedical Engineering Program, Alberto Luiz Coimbra Institute of Post-Graduation and Research in Engineering, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Miriam Menna Barreto - Universidade Federal do Rio de Janeiro
Walter Araujo Zin - Universidade Federal do Rio de Janeiro
Júlia De Toledo-Mendes - Universidade Federal do Rio de Janeiro
Philippe Alcantara G. Martins - Universidade Federal do Rio de Janeiro
Sergio Altino De Almeida - D’Or Institute for Research and Education
Rodrigo Basílio - D’Or Institute for Research and Education
Remy Martins-Gonçalves - Fundação Oswaldo Cruz
Eugênio Damaceno Hottz - Fundação Oswaldo Cruz
Patricia T. Bozza - Fundação Oswaldo Cruz
Fernando A. Bozza - D’Or Institute for Research and Education
Alysson Roncally Silva Carvalho - D’Or Institute for Research and Education
Paulo Henrique Rosado-De-Castro - Universidade Federal do Rio de Janeiro
Resource Type: Journal article
Publication Details: Clinical nuclear medicine, Vol.47(12), pp.1019-1025
DOI: 10.1097/RLU.0000000000004376
PMID: 36026599
PMCID: PMC9653065
NLM abbreviation: Clin Nucl Med
ISSN: 0363-9762
eISSN: 1536-0229
Number of pages: 7
Grant note: Instituto D'Or de Pesquisa e Ensino (http://data.elsevier.com/vocabulary/SciValFunders/100020326) E-26/202.751/2018; E-26/202.785/2017; E-26/203.001/2018; E-26/203.279/2017; E-26/211.867/2016 / Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (http://data.elsevier.com/vocabulary/SciValFunders/501100004586) Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (http://data.elsevier.com/vocabulary/SciValFunders/501100004586) 02839/2017-8; 302702/2017-2; 312410/2017-4 / Conselho Nacional de Desenvolvimento Científico e Tecnológico (http://data.elsevier.com/vocabulary/SciValFunders/501100003593) Conselho Nacional de Desenvolvimento Científico e Tecnológico (http://data.elsevier.com/vocabulary/SciValFunders/501100003593)
Language: English
Date published: 12/01/2022
Academic Unit: Radiology
Record Identifier: 9985143552802771

Metrics

1 Record Views