Journal article
Increased P-selectin expression on platelets and decreased plasma thrombomodulin in Fontan patients
Circulation journal : official journal of the Japanese Circulation Society, Vol.73(9), pp.1705-1710
2009
DOI: 10.1253/circj.CJ-08-1087
PMID: 19638712
Abstract
Background: Thromboembolic events account for significant morbidity and mortality after the Fontan procedure, but the underlying mechanisms remain unclear. P-selectin on platelets indicates platelet activation. Thrombomodulin (TM), a receptor for thrombin and a major anticoagulant proteoglycan on the endothelial membrane, reflects the anticoagulant activity of the endothelium. The present study investigated the hypothesis that the balance between platelet activation and endothelial biological function is impaired in Fontan patients. Methods and Results: Platelet P-selectin as a marker of platelet activation, plasma TM levels and protein C activity, as markers of anticoagulant activity of the endothelium, and thrombin-antithrombin complex III (TAT) were examined in 43 Fontan patients. P-selectin levels on platelets (4.5 ±1.4 vs 3.4 ±0.4 mean fluorescence intensity, P<0.001) and TAT levels (80.2 ±322.6 vs 1.9 ±0.9 ng/ml, P<0.05) were significantly higher in Fontan patients than in control subjects. On the other hand, plasma TM levels (1.5 ±0.8 vs 2.2 ±0.3 FU/ml, P<0.01) and protein C activity (71 ±35 vs 118 ±25%, P<0.001) were significantly lower in Fontan patients compared with controls. These abnormalities were not seen in patients after other surgical procedures for congenital heart disease. Conclusions: Platelet activation is enhanced and endothelial function is impaired in patients after the Fontan procedure, which may partly explain the thromboembolic complications in Fontan patients.
Details
- Title: Subtitle
- Increased P-selectin expression on platelets and decreased plasma thrombomodulin in Fontan patients
- Creators
- Hidemi Kajimoto - Tokyo Women's Medical UniversityMakoto Nakazawa - Southern Tohoku General HospitalKagari Murasaki - Tokyo Women's Medical UniversityNobuhisa Hagiwara - Tokyo Women's Medical UniversityToshio Nakanishi - Tokyo Women's Medical University
- Resource Type
- Journal article
- Publication Details
- Circulation journal : official journal of the Japanese Circulation Society, Vol.73(9), pp.1705-1710
- DOI
- 10.1253/circj.CJ-08-1087
- PMID
- 19638712
- NLM abbreviation
- Circ J
- ISSN
- 1346-9843
- eISSN
- 1347-4820
- Number of pages
- 6
- Language
- English
- Date published
- 2009
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984961028302771
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