Journal article
Increased Risk of Herpes Zoster in Children with Asthma: A Population-Based Case-Control Study
The Journal of pediatrics, Vol.163(3), pp.816-821
09/2013
DOI: 10.1016/j.jpeds.2013.03.010
PMCID: PMC3728177
PMID: 23587434
Abstract
To determine the risk of herpes zoster (HZ) in children with and without asthma.
This study was designed as a population-based case-control study. We examined all children (aged <18 years) with possible HZ in Olmsted County, Minnesota, between 1996 and 2001 (n = 306; identified by International Classification of Diseases, Eighth Revision codes and predetermined criteria for HZ) to identify true cases. To determine the association between asthma and HZ, we compared the frequency of asthma among children with HZ with that among age- and sex-matched corresponding controls (1:1 matching) who resided in Olmsted County, Minnesota, during the study period. Asthma was ascertained based on predetermined criteria. A conditional logistic regression model was used to calculate ORs and 95% CIs.
We identified 277 eligible patients with HZ, 63 (23%) of whom had a history of asthma before the index date of HZ, compared with 35 of 277 (12.6%) matched controls (aOR, 2.09; 95% CI, 1.24-3.52; P = .006), adjusting for varicella vaccination and atopy status. The population-attributable risk percentage was 12%. Controlling for asthma and atopy status, varicella vaccination was associated with reduced risk of HZ (aOR, 0.44; 95% CI, 0.21-0.92; P = .028).
Asthma may be an unrecognized risk factor for reactivation of a non–airway-related latent infection such as HZ in children.
Details
- Title: Subtitle
- Increased Risk of Herpes Zoster in Children with Asthma: A Population-Based Case-Control Study
- Creators
- Bong-Seong Kim - Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MNSonia Mehra - Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MNBarbara Yawn - Department of Research, Olmsted Medical Center, Rochester, MNCharles Grose - Virology Laboratory, Children’s Hospital, University of Iowa, Iowa City, IARobert Tarrell - Department of Health Sciences Research, Mayo Clinic, Rochester, MNBrian Lahr - Department of Health Sciences Research, Mayo Clinic, Rochester, MNYoung J Juhn - Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.163(3), pp.816-821
- DOI
- 10.1016/j.jpeds.2013.03.010
- PMID
- 23587434
- PMCID
- PMC3728177
- NLM abbreviation
- J Pediatr
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Publisher
- Elsevier Inc
- Grant note
- Mayo Foundation R01 AG34676 / National Institute on Aging R21 AI101277 / UK National Immunization Council
- Language
- English
- Date published
- 09/2013
- Academic Unit
- Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984093373202771
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