Journal article
Increased Serum C-reactive Protein and Corpus Callosum Alterations in Older Adults
Aging and disease, Vol.10(2), pp.463-469
04/01/2019
DOI: 10.14336/AD.2018.0329
PMCID: PMC6457060
PMID: 31011488
Abstract
Chronic systemic low-grade inflammation is associated with aging, but little is known on whether age-related inflammation affects brain structure, particularly white matter. The current study tested the hypothesis that in older adults without dementia, higher serum levels of high-sensitivity C-reactive protein (hs-CRP) are associated with reduced corpus callosum (CC) areas. French community-dwelling subjects (ESPRIT study) aged 65 and older (N=101) underwent hs-CRP testing and structural magnetic resonance imaging (MRI). Multiple linear regression models were carried out. In the unadjusted model, higher hs-CRP level was significantly associated with smaller anterior, mid, and total midsagittal CC areas, but not with the posterior CC area. These associations were independent of demographic characteristics and intracranial volume. After adjustment for body mass index, diabetes, inflammation-related chronic pathologies and white matter lesions (WML), only the associations between hs-CRP level and smaller anterior and total midsagittal CC areas were still significant, although weaker. These findings suggest that low-grade inflammation is associated with CC structural integrity alterations in older adults independently of physical or neuropsychiatric pathologies.
Details
- Title: Subtitle
- Increased Serum C-reactive Protein and Corpus Callosum Alterations in Older Adults
- Creators
- Fabienne Cyprien - InsermPhilippe Courtet - Université de MontpellierJerome Maller - Monash Alfred Psychiatry Research centreChantal Meslin - Australian National UniversityKaren Ritchie - Université de MontpellierMarie-Laure Ancelin - InsermSylvaine Artero - Inserm
- Resource Type
- Journal article
- Publication Details
- Aging and disease, Vol.10(2), pp.463-469
- DOI
- 10.14336/AD.2018.0329
- PMID
- 31011488
- PMCID
- PMC6457060
- NLM abbreviation
- Aging Dis
- ISSN
- 2152-5250
- eISSN
- 2152-5250
- Publisher
- Int Soc Aging & Disease
- Number of pages
- 7
- Language
- English
- Date published
- 04/01/2019
- Academic Unit
- Radiology
- Record Identifier
- 9984848510502771
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