Journal article
Increased Thrombogenesity in Patients With Cyanotic Congenital Heart Disease
Circulation journal : official journal of the Japanese Circulation Society, Vol.71(6), pp.948-953
2007
DOI: 10.1253/circj.71.948
PMID: 17526995
Abstract
Background The basic mechanisms of thromboembolism in cyanotic congenital heart disease (CCHD) have not been well clarified. P-selectin on the platelets reflects platelet activation. Thrombomodulin is a critical cofactor for thrombin-mediated activation of protein C and reflects the anticoagulant activity of the endothelium. The present study was performed to evaluate whether platelet activation exists in patients with CCHD. Methods and Results Platelet P-selectin as a marker of platelet activation, plasma thrombomodulin level and protein C activity as markers of anticoagulant activity of the endothelium and thrombin - antithrombin complex III (TAT) were examined in 35 patients with CCHD. Plasma thrombomodulin level (1.1±0.9 vs 2.2±0.3 FU/ml) and protein C activity (71.1±29.8 vs 117.8±24.8%) were significantly lower in patients with CCHD as compared with the control subjects. The levels of plasma TAT (255±811 vs 1.9±0.9 ng/ml) and P-selectin on platelets (6.3 ±4.5 vs 3.3±0.3 mean fluorescence intensity) were significantly higher in the patients with CCHD than in the controls. Four of the CCHD patients who experienced thromboembolic events had elevated levels of platelet P-selectin (p=0.02) compared with CCHD patients without thromboembolic events. Conclusion Platelet activation exists in patients with CCHD and it may play an important role in the thromboembolic events in CCHD.
Details
- Title: Subtitle
- Increased Thrombogenesity in Patients With Cyanotic Congenital Heart Disease
- Creators
- Hidemi Kajimoto - Tokyo Women's Medical UniversityMakoto Nakazawa - Tokyo Women's Medical UniversityKagari Murasaki - Tokyo Women's Medical UniversityYoshiki Mori - Tokyo Women's Medical UniversityKenjiro Tanoue - Tokyo Women's Medical UniversityHiroshi Kasanuki - Tokyo Women's Medical UniversityToshio Nakanishi - Tokyo Women's Medical University
- Resource Type
- Journal article
- Publication Details
- Circulation journal : official journal of the Japanese Circulation Society, Vol.71(6), pp.948-953
- DOI
- 10.1253/circj.71.948
- PMID
- 17526995
- NLM abbreviation
- Circ J
- ISSN
- 1346-9843
- eISSN
- 1347-4820
- Number of pages
- 6
- Language
- English
- Date published
- 2007
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984961029202771
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