Journal article
Increased acetylcholine availability in the early stages of heart failure in rats: effects on cardiac autonomic tone and left ventricular function
The FASEB journal, Vol.25, pp.646.11-646.11
04/2011
DOI: 10.1096/fasebj.25.1_supplement.646.11
Abstract
We investigated the cardiac autonomic tone and left ventricle function (LVF) in heart failure rats subjected to pyridostigmine (PYR) to increase acetylcholine availability. Male rats had the left coronary artery ligated (HF) or were sham‐operated (SHAM) and received osmotic pumps to deliver PYR (700 μg/day) or saline for 12 days. Three days before the experiment, rats were implanted with femoral artery and vein catheters and the cardiac autonomic tone was evaluated by atropine and propranolol. LVF was evaluated through Millar and echocardiographic recordings. PYR decreased basal heart rate (HR) in SHAM (313 ± 1 vs 290 ± 4 bpm) and HF rats (366 ± 7 vs 307 ± 5 bpm) and increased the tachycardia elicited by atropine in SHAM (101 ± 1 vs 139 ± 6 bpm) and HF rats (19 ± 1 vs 82 ± 5 bpm). HF rats receiving saline showed higher basal HR (313 ± 1 vs 366 ± 7 bpm), reduced tachycardia elicited by atropine (101 ± 1 vs 19 ± 1 bpm) and greater bradycardia elicited by propranolol (2 ± 1 vs 25 ± 6 bpm). PYR did not change +dP/dt, −dP/dt and ejection fraction (EF) in SHAM or HF rats. Nevertheless, HF rats receiving saline showed decreased +dP/dt (8708 ± 301 vs 5764 ± 206 mmHg/s), −dP/dt (10498 ± 398 vs 4007 ± 206 mmHg/s) and EF (69 vs 38 %) as compared to SHAM rats. In conclusion, increased acetylcholine availability prevented cardiac autonomic dysfunction and tachycardia observed in the early stages of HF in rats.
Support: HL14388; MH080241; DK66086; HL98207; CAPES
Details
- Title: Subtitle
- Increased acetylcholine availability in the early stages of heart failure in rats: effects on cardiac autonomic tone and left ventricular function
- Creators
- Daniel Penteado Martins Dias - School of Medicine of Ribeirao Preto USPRubens Fazan - School of Medicine of Ribeirao Preto USPHelio Cesar Salgado - School of Medicine of Ribeirao Preto USPTerry Beltz - University of IowaAlan Kim Johnson - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The FASEB journal, Vol.25, pp.646.11-646.11
- Publisher
- Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.25.1_supplement.646.11
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Grant note
- CAPES (HL14388; MH080241; DK66086; HL98207)
- Language
- English
- Date published
- 04/2011
- Academic Unit
- Health and Human Physiology; Psychological and Brain Sciences; Neuroscience and Pharmacology
- Record Identifier
- 9984213404402771
Metrics
1 Record Views