Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS

William Z Zhang; Clara Oromendia; Sarah Ann Kikkers; James J Butler; Sarah O'Beirne; Kihwan Kim; Wanda K O'Neal; Christine M Freeman; Stephanie A Christenson; Stephen P Peters; J Michael Wells; Claire Doerschuk; Nirupama Putcha; Igor Barjaktarevic; Prescott G Woodruff; Christopher B Cooper; Russell P Bowler; Alejandro P Comellas; Gerard J Criner; Robert Paine III; Nadia N Hansel; Meilan K Han; Ronald G Crystal; Robert J Kaner; Karla V Ballman; Jeffrey L Curtis; Fernando J Martinez; Suzanne M Cloonan

doi:10.1038/s41598-020-67047-w

Back

Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS

Journal article

Open access

Peer reviewed

Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS

William Z Zhang, Clara Oromendia, Sarah Ann Kikkers, James J Butler, Sarah O'Beirne, Kihwan Kim, Wanda K O'Neal, Christine M Freeman, Stephanie A Christenson, Stephen P Peters, …

Scientific reports, Vol.10(1), pp.10562-10562

06/29/2020

DOI: 10.1038/s41598-020-67047-w

PMCID: PMC7324559

PMID: 32601308

Files and links (1)

url

https://doi.org/10.1038/s41598-020-67047-wView

Published (Version of record) Open Access

Abstract

Levels of iron and iron-related proteins including ferritin are higher in the lung tissue and lavage fluid of individuals with chronic obstructive pulmonary disease (COPD), when compared to healthy controls. Whether more iron in the extracellular milieu of the lung associates with distinct clinical phenotypes of COPD, including increased exacerbation susceptibility, is unknown. We measured iron and ferritin levels in the bronchoalveolar lavage fluid (BALF) of participants enrolled in the SubPopulations and InteRmediate Outcome Measures In COPD (SPIROMICS) bronchoscopy sub-study (n = 195). BALF Iron parameters were compared to systemic markers of iron availability and tested for association with FEV % predicted and exacerbation frequency. Exacerbations were modelled using a zero-inflated negative binomial model using age, sex, smoking, and FEV % predicted as clinical covariates. BALF iron and ferritin were higher in participants with COPD and in smokers without COPD when compared to non-smoker control participants but did not correlate with systemic iron markers. BALF ferritin and iron were elevated in participants who had COPD exacerbations, with a 2-fold increase in BALF ferritin and iron conveying a 24% and 2-fold increase in exacerbation risk, respectively. Similar associations were not observed with plasma ferritin. Increased airway iron levels may be representative of a distinct pathobiological phenomenon that results in more frequent COPD exacerbation events, contributing to disease progression in these individuals.

Adult

Aged

Aged, 80 and over

Biomarkers - blood

Bronchoalveolar Lavage Fluid - chemistry

Disease Progression

Female

Ferritins - metabolism

Forced Expiratory Volume

Humans

Iron - metabolism

Iron - physiology

Iron-Binding Proteins - metabolism

Iron-Binding Proteins - physiology

Lung - metabolism

Male

Middle Aged

Pulmonary Disease, Chronic Obstructive - metabolism

Pulmonary Disease, Chronic Obstructive - physiopathology

Respiratory Function Tests

Risk Factors

Severity of Illness Index

Details

Title: Subtitle: Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS
Creators: William Z Zhang - Weill Cornell Medicine
Clara Oromendia - Weill Cornell Medicine
Sarah Ann Kikkers - Weill Cornell Medicine
James J Butler - Weill Cornell Medicine
Sarah O'Beirne - University of North Carolina at Chapel Hill
Kihwan Kim - Weill Cornell Medicine
Wanda K O'Neal - University of North Carolina at Chapel Hill
Christine M Freeman - University of Michigan
Stephanie A Christenson - University of North Carolina at Chapel Hill
Stephen P Peters - University of North Carolina at Chapel Hill
J Michael Wells - University of Alabama at Birmingham
Claire Doerschuk - University of North Carolina at Chapel Hill
Nirupama Putcha - Johns Hopkins Medicine
Igor Barjaktarevic - Los Angeles Medical Center
Prescott G Woodruff - University of North Carolina at Chapel Hill
Christopher B Cooper - Los Angeles Medical Center
Russell P Bowler - University of North Carolina at Chapel Hill
Alejandro P Comellas - University of Iowa
Gerard J Criner - Temple University
Robert Paine III - University of North Carolina at Chapel Hill
Nadia N Hansel - Johns Hopkins Medicine
Meilan K Han - University of Michigan
Ronald G Crystal - Weill Cornell Medicine
Robert J Kaner - Weill Cornell Medicine
Karla V Ballman - Weill Cornell Medicine
Jeffrey L Curtis - University of Michigan
Fernando J Martinez - Weill Cornell Medicine
Suzanne M Cloonan - Weill Cornell Medicine
Resource Type: Journal article
Publication Details: Scientific reports, Vol.10(1), pp.10562-10562
DOI: 10.1038/s41598-020-67047-w
PMID: 32601308
PMCID: PMC7324559
NLM abbreviation: Sci Rep
ISSN: 2045-2322
eISSN: 2045-2322
Grant note: HHSN268200900017C / NHLBI NIH HHS P30 ES005605 / NIEHS NIH HHS HHSN268200900019C / NHLBI NIH HHS HHSN268200900020C / NHLBI NIH HHS U24 HL141762 / NHLBI NIH HHS U01 HL137880 / NHLBI NIH HHS HHSN268200900015C / NHLBI NIH HHS P01 HL114501 / NHLBI NIH HHS HHSN268200900013C / NHLBI NIH HHS R01 HL122438 / NHLBI NIH HHS R01 HL136682 / NHLBI NIH HHS K24 HL137013 / NHLBI NIH HHS HHSN268200900016C / NHLBI NIH HHS HHSN268200900018C / NHLBI NIH HHS HHSN268200900014C / NHLBI NIH HHS U01 HL128964 / NHLBI NIH HHS R00 HL125899 / NHLBI NIH HHS T32 HL134629 / NHLBI NIH HHS
Language: English
Date published: 06/29/2020
Academic Unit: Pulmonary, Critical Care, and Occupational Medicine; ICTS; Internal Medicine
Record Identifier: 9984359816202771

Metrics

24 Record Views

25 Times Cited - Web of Science