Journal article
Increased cellular activity in rat insular cortex after water and salt ingestion induced by fluid depletion
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.284(4), pp.R1119-1125
04/2003
DOI: 10.1152/ajpregu.00189.2002
PMID: 12505866
Abstract
Insular cortex (IC) receives inputs from multiple sensory systems, including taste, and from receptors that monitor body electrolyte and fluid balance and blood pressure. This work analyzed metabolic activity of IC cells after water and sodium ingestion induced by sodium depletion. Rats were injected with the diuretic furosemide (10 mg/kg body wt), followed 5 min later by injections of the angiotensin-converting enzyme inhibitor captopril (5 mg/kg body wt). After 90 min, some rats received water and 0.3 M NaCl to drink for 2 h while others did not. A third group had access to water and saline but was not depleted of fluids. All rats were killed for processing of brain tissue for Fos-immunoreactivity (Fos-ir). Nondepleted animals had weak-to-moderate levels of Fos-ir within subregions of IC. Fluid-depleted rats without fluid access had significantly increased Fos-ir in all areas of IC. Levels of Fos-ir were highest in fluid-depleted rats that drank water and sodium. Fos-ir levels were highest in anterior regions of IC and lowest in posterior regions of IC. These results implicate visceral, taste, and/or postingestional factors in the increased metabolic activity of cells in IC.
Details
- Title: Subtitle
- Increased cellular activity in rat insular cortex after water and salt ingestion induced by fluid depletion
- Creators
- Cinthia V Pastuskovas - Department of Psychology, University of Iowa, Iowa City, Iowa 52242-1407, USAMartin D CassellAlan Kim JohnsonRobert L Thunhorst
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.284(4), pp.R1119-1125
- DOI
- 10.1152/ajpregu.00189.2002
- PMID
- 12505866
- ISSN
- 0363-6119
- eISSN
- 1522-1490
- Grant note
- HL-54292 / NHLBI NIH HHS HL-57472 / NHLBI NIH HHS MH-59239 / NIMH NIH HHS HL-14388 / NHLBI NIH HHS
- Language
- English
- Date published
- 04/2003
- Academic Unit
- Anatomy and Cell Biology; Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213272802771
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