Journal article
Increased circulating Wnt5a protein in patients with rheumatoid arthritis-associated interstitial pneumonia (RA-ILD)
Immunobiology (1979), Vol.224(4), pp.551-559
07/2019
DOI: 10.1016/j.imbio.2019.04.006
PMID: 31072629
Abstract
•An increased Wnt5a protein in the plasma of patients with rheumatoid arthritis- associated interstitial lung disease (RA-ILD).•The Wnt5a protein correlates to the usual interstitial pneumonia (UIP) pattern of RA-ILD.•The Wnt5a protein was associated with the severity and smoking status of RA-ILD.•The age, RA duration, smoking and plasma Wnt5a were risk factors in RA-ILD patients.•The circulating Wnt5a protein was a potential biomarker for identifying patients with RA-UIP.
An early diagnosis of interstitial lung disease (ILD) is important for guiding treatments of rheumatoid arthritis (RA)-associated ILD (RA-ILD) in clinical settings. The non-canonical Wnt signaling representative ligand Wnt5a was recently found to involve in idiopathic pulmonary fibrosis (IPF) and pathogenesis of RA. The goal of this study was to examine the clinical relevance of Wnt5a in RA-ILD. In this report, the clinical relevance of plasma Wnt5a protein was evaluated in 40 RA-ILD patients and 41 non-ILD RA cohorts. The results showed an elevated Wnt5a protein in plasmas of RA-ILD patients compared with non-ILD RA patients (p < 0.01), which was positively correlated with the plasma level of rheumatoid factor (RF). Of note, more abundant Wnt5a was also found in patients with usual interstitial pneumonia (UIP) than those with nonspecific interstitial pneumonia (NSIP) and other ILD patterns. More importantly, the disease severity was correlated with the circulating Wnt5a as ascertained by high-resolution computed tomography (HRCT)-UIP scores. The multiple-factor non-conditional logistic regression analysis further revealed that the age, RA duration, smoking and plasma Wnt5a were risk factors with clinical significance for RA-ILD. Interestingly, more Wnt5a-positive patients were identified in RA-ILD smokers relative to RA-ILD never-smokers, and longer smoking duration was strongly correlated with Wnt5a in RA-ILD patients. In consistence, ROC curve also suggested that the Wnt5a was a potential candidate biomarker for identifying patients with RA-UIP. These results demonstrate that the circulating Wnt5a may be a risk factor and potential biomarker for identifying UIP and accessing the severity and progression of ILD in RA patients.
Details
- Title: Subtitle
- Increased circulating Wnt5a protein in patients with rheumatoid arthritis-associated interstitial pneumonia (RA-ILD)
- Creators
- Miao Yu - Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western, and College of Life Science, Ningxia University, Yinchuan, Ningxia 750021, ChinaYuanyuan Guo - Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western, and College of Life Science, Ningxia University, Yinchuan, Ningxia 750021, ChinaPeng Zhang - Department of Pulmonary and Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, ChinaJing Xue - Department of Pulmonary and Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, ChinaJiali Yang - Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western, and College of Life Science, Ningxia University, Yinchuan, Ningxia 750021, ChinaQian Cai - Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western, and College of Life Science, Ningxia University, Yinchuan, Ningxia 750021, ChinaXuehong You - Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western, and College of Life Science, Ningxia University, Yinchuan, Ningxia 750021, ChinaJia Ma - Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western, and College of Life Science, Ningxia University, Yinchuan, Ningxia 750021, ChinaDandan Yang - Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western, and College of Life Science, Ningxia University, Yinchuan, Ningxia 750021, ChinaYuanyuan Jia - Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western, and College of Life Science, Ningxia University, Yinchuan, Ningxia 750021, ChinaYujiong Wang - Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western, and College of Life Science, Ningxia University, Yinchuan, Ningxia 750021, ChinaFeng Li - Department of Rheumatology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, ChinaShuhong Chi - Department of Rheumatology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, ChinaMengshu Cao - Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, ChinaJuan Chen - Department of Pulmonary and Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, ChinaXiaoming Liu - Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western, and College of Life Science, Ningxia University, Yinchuan, Ningxia 750021, China
- Resource Type
- Journal article
- Publication Details
- Immunobiology (1979), Vol.224(4), pp.551-559
- Publisher
- Elsevier GmbH
- DOI
- 10.1016/j.imbio.2019.04.006
- PMID
- 31072629
- ISSN
- 0171-2985
- eISSN
- 1878-3279
- Grant note
- DOI: 10.13039/501100001809, name: National Natural Science Foundation of China, award: 31860318, 8176004, 81860132; name: First-Class Discipline Construction Founded Project of Ningxia Medical University and the School of Clinical Medicine, award: NXYLXK2017A05; name: Natural Science Foundation of Ningxia, award: NZ17169, NZ17161; DOI: 10.13039/501100004179, name: Ningxia Medical University, award: XZ2017009
- Language
- English
- Date published
- 07/2019
- Academic Unit
- Anatomy and Cell Biology
- Record Identifier
- 9984025447302771
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