Journal article
Increased contrast enhancement of the parent vessel of unruptured intracranial aneurysms in 7T MR imaging
Journal of neurointerventional surgery, Vol.12(10), pp.1018-1022
10/2020
DOI: 10.1136/neurintsurg-2020-015915
PMID: 32424006
Abstract
BackgroundInflammation of the arterial wall may lead to aneurysm formation. The presence of aneurysm enhancement on high-resolution vessel wall imaging (HR-VWI) is a marker of wall inflammation and instability. We aim to determine if there is any association between increased contrast enhancement in the aneurysmal wall and its parent artery.MethodsPatients with unruptured intracranial aneurysms (UIAs) prospectively underwent 7T HR-VWI. Regions of interest were selected manually and with a semi-automated protocol based on gradient algorithms of intensity patterns. Mean signal intensities in pre- and post-contrast T1-weighted sequences were adjusted to the enhancement of the pituitary stalk and then subtracted to objectively determine: circumferential aneurysmal wall enhancement (CAWE); parent vessel enhancement (PVE); and reference vessel enhancement (RVE). PVE was assessed over regions located 3- and 5 mm from the aneurysm’s neck. RVE was assessed in arteries located in a different vascular territory.ResultsTwenty-five UIAs were analyzed. There was a significant moderate correlation between CAWE and 5 mm PVE (Pearson R=0.52, P=0.008), whereas no correlation was found between CAWE and RVE (Pearson R=0.20, P=0.33). A stronger correlation was found between CAWE and 3 mm PVE (Pearson R=0.78, P<0.001). Intra-class correlation analysis demonstrated good reliability between measurements obtained using semi-automated and manual segmentation (ICC coefficient=0.790, 95% CI 0.58 to 0.90).ConclusionParent arteries exhibit higher contrast enhancement in regions closer to the aneurysm’s neck, especially in aneurysms≥7 mm. A localized inflammatory/vasculopathic process in the wall of the parent artery may lead to aneurysm formation and growth.
Details
- Title: Subtitle
- Increased contrast enhancement of the parent vessel of unruptured intracranial aneurysms in 7T MR imaging
- Creators
- Edgar A Samaniego - Interventional Neuroradiology/Endovascular Neurosurgery Division Department of Neurology, Neurosurgery and Radiology, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, USAJorge A Roa - Department of Neurology and Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USAHonghai Zhang - Department of Electrical and Computer Engineering, Iowa Institute of Biomedical Imaging, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USATimothy R Koscik - Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USASantiago Ortega-Gutierrez - Interventional Neuroradiology/Endovascular Neurosurgery Division Department of Neurology, Neurosurgery and Radiology, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, USAGirish Bathla - Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USAMilan Sonka - Department of Electrical and Computer Engineering, Iowa Institute of Biomedical Imaging, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USAColin Derdeyn - Radiology and Interventional Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USAVincent A Magnotta - Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USADavid Hasan - Neurological Surgery, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Journal of neurointerventional surgery, Vol.12(10), pp.1018-1022
- DOI
- 10.1136/neurintsurg-2020-015915
- PMID
- 32424006
- NLM abbreviation
- J Neurointerv Surg
- ISSN
- 1759-8478
- eISSN
- 1759-8486
- Grant note
- name: The Bee Foundation, award: 2019 Brain Aneurysm Research Grant; name: Society of Vascular and Interventional Neurology, award: 2019 Pilot Research Grant
- Language
- English
- Date published
- 10/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Electrical and Computer Engineering; Psychiatry; Iowa Neuroscience Institute; Radiation Oncology; Injury Prevention Research Center; Neurosurgery; Otolaryngology; Ophthalmology and Visual Sciences
- Record Identifier
- 9984066380602771
Metrics
13 Record Views