Journal article
Increased cortical thickness in nodes of the cognitive control and default mode networks in psychosis of epilepsy
Seizure (London, England), Vol.101, pp.244-252
10/01/2022
DOI: 10.1016/j.seizure.2022.09.006
PMID: 36116283
Abstract
Objective: To explore the cortical morphological associations of the psychoses of epilepsy. Methods: Psychosis of epilepsy (POE) has two main subtypes - postictal psychosis and interictal psychosis. We used automated surface-based analysis of magnetic resonance images to compare cortical thickness, area, and volume across the whole brain between: (i) all patients with POE (n = 23) relative to epilepsy-without psychosis controls (EC; n = 23), (ii) patients with interictal psychosis (n = 10) or postictal psychosis (n = 13) relative to EC, and (iii) patients with postictal psychosis (n = 13) relative to patients with interictal psychosis (n = 10). Results: POE is characterised by cortical thickening relative to EC, occurring primarily in nodes of the cognitive control network; (rostral anterior cingulate, caudal anterior cingulate, middle frontal gyrus), and the default mode network (posterior cingulate, medial paracentral gyrus, and precuneus). Patients with interictal psychosis displayed cortical thickening in the left hemisphere in occipital and temporal regions relative to EC (lateral occipital cortex, lingual, fusiform, and inferior temporal gyri), which was evident to a lesser extent in postictal psychosis patients. There were no significant differences in cortical thickness, area, or volume between the postictal psychosis and EC groups, or between the postictal psychosis and interictal psychosis groups. However, prior to correction for multiple comparisons, both the interictal psychosis and postictal psychosis groups displayed cortical thickening relative to EC in highly similar regions to those identified in the POE group overall. Significance: The results show cortical thickening in POE overall, primarily in nodes of the cognitive control and default mode networks, compared to patients with epilepsy without psychosis. Additional thickening in temporal and occipital neocortex implicated in the dorsal and ventral visual pathways may differentiate interictal psychosis from postictal psychosis. A novel mechanism for cortical thickening in POE is proposed whereby normal synaptic pruning processes are interrupted by seizure onset.
Details
- Title: Subtitle
- Increased cortical thickness in nodes of the cognitive control and default mode networks in psychosis of epilepsy
- Creators
- James Allebone - Florey Institute of Neuroscience and Mental HealthSarah J. Wilson - Austin HealthRichard C. J. Bradlow - Eastern HealthJerome Maller - Monash Alfred Psychiatry Research centreTerry O' Brien - Royal Melbourne Hosp, Melbourne, Vic, AustraliaSaul A. Mullen - Florey Institute of Neuroscience and Mental HealthMark Cook - The University of MelbourneSophia J. Adams - Austin HealthSimon Vogrin - St Vincent's Hospital MelbourneDavid N. Vaughan - Austin HealthAlan Connelly - Austin HealthPatrick Kwan - Monash UniversitySamuel F. Berkovic - Austin HealthWendyl J. DSouza - The University of MelbourneGraeme Jackson - Austin HealthDennis Velakoulis - The Royal Melbourne HospitalRichard A. Kanaan - The University of Melbourne
- Resource Type
- Journal article
- Publication Details
- Seizure (London, England), Vol.101, pp.244-252
- DOI
- 10.1016/j.seizure.2022.09.006
- PMID
- 36116283
- NLM abbreviation
- Seizure
- ISSN
- 1059-1311
- eISSN
- 1532-2688
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- Australian Postgraduate Award; Australian Government
- Language
- English
- Date published
- 10/01/2022
- Academic Unit
- Radiology
- Record Identifier
- 9984848423102771
Metrics
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