Increased expression of activity-dependent genes in cerebellar glutamatergic neurons of patients with schizophrenia

Rodrigo D Paz; Nancy C Andreasen; Sami Z Daoud; Robert Conley; Rosalinda Roberts; Juan Bustillo; Nora I Perrone-Bizzozero

doi:10.1176/ajp.2006.163.10.1829

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Increased expression of activity-dependent genes in cerebellar glutamatergic neurons of patients with schizophrenia

Journal article

Peer reviewed

Increased expression of activity-dependent genes in cerebellar glutamatergic neurons of patients with schizophrenia

Rodrigo D Paz, Nancy C Andreasen, Sami Z Daoud, Robert Conley, Rosalinda Roberts, Juan Bustillo and Nora I Perrone-Bizzozero

The American journal of psychiatry, Vol.163(10), pp.1829-1831

10/2006

DOI: 10.1176/ajp.2006.163.10.1829

PMID: 17012697

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Abstract

The purpose of this study was to evaluate the functional state of glutamatergic neurons in the cerebellar cortex of patients with schizophrenia. The authors measured messenger ribonucleic acid (mRNA) levels of three activity-dependent genes expressed by glutamatergic neurons in the cerebellar cortex (GAP-43, BDNF, and GABA OLE_LINK2>(A)-delta subunit) in the tissues of 14 patients with schizophrenia and 14 matched nonpsychiatric comparison subjects. Since its level of expression does not change in response to neuronal activity, gamma-aminobutyric acid(A)-alpha6 subunit mRNA was used as a control. The levels of GAP-43 and BDNF mRNAs were significantly elevated in patients with schizophrenia, and a similar finding was observed for GABA(A)-delta mRNA. In contrast, the levels of the GABA(A)-alpha6 subunit mRNA, which is expressed in cerebellar granule cells in an activity-independent manner, did not differ from comparison subjects. These results suggest that glutamatergic neurons may be hyperactive in the cerebellar cortices of patients with schizophrenia.

Schizophrenia - metabolism

Neurons - chemistry

GAP-43 Protein - metabolism

Gene Expression Regulation - genetics

gamma-Aminobutyric Acid - metabolism

Cerebellar Cortex - metabolism

Cerebellum - metabolism

Humans

Middle Aged

RNA, Messenger - analysis

Male

RNA, Messenger - metabolism

Schizophrenia - genetics

Receptors, GABA-A - genetics

Adult

Female

Aged

Brain-Derived Neurotrophic Factor - metabolism

Cerebellum - chemistry

Glutamic Acid - metabolism

Neurons - metabolism

Receptors, GABA-A - metabolism

Details

Title: Subtitle: Increased expression of activity-dependent genes in cerebellar glutamatergic neurons of patients with schizophrenia
Creators: Rodrigo D Paz - Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, 87131, USA
Nancy C Andreasen
Sami Z Daoud
Robert Conley
Rosalinda Roberts
Juan Bustillo
Nora I Perrone-Bizzozero
Resource Type: Journal article
Publication Details: The American journal of psychiatry, Vol.163(10), pp.1829-1831
Publisher: United States
DOI: 10.1176/ajp.2006.163.10.1829
PMID: 17012697
ISSN: 0002-953X
eISSN: 1535-7228
Language: English
Date published: 10/2006
Academic Unit: Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003923402771

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