Increased hospitalizations among sarcoidosis patients from 1998 to 2008: a population-based cohort study

Alicia K Gerke; Ming Yang; Fan Tang; Joseph E Cavanaugh; Philip M Polgreen

doi:10.1186/1471-2466-12-19

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Increased hospitalizations among sarcoidosis patients from 1998 to 2008: a population-based cohort study

Journal article

Open access

Peer reviewed

Increased hospitalizations among sarcoidosis patients from 1998 to 2008: a population-based cohort study

Alicia K Gerke, Ming Yang, Fan Tang, Joseph E Cavanaugh and Philip M Polgreen

BMC pulmonary medicine, Vol.12(1), pp.19-19

07/09/2012

DOI: 10.1186/1471-2466-12-19

PMCID: PMC3391973

PMID: 22584044

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Abstract

Diagnostic and treatment approaches for sarcoidosis have changed dramatically over the past decade. Yet, the most recent reports of trends in hospitalizations of sarcoidosis patients are over ten years old. The objectives of this study were to determine the incidence of sarcoidosis among hospitalized patients and to analyze recent trends and seasonality of hospitalizations in sarcoidosis patients. We performed a retrospective cohort study of the Nationwide Inpatient Sample from 1998 through 2008. We identified all hospitalizations with a primary or secondary diagnosis of sarcoidosis (ICD-9-CM code 135). Incidence was modeled as a seasonal time series about a linear trend. Time series analysis of the monthly number of hospitalizations revealed a distinct positive linear trend. Over the study period, the number of hospitalized patients with sarcoidosis increased from 37,516 to 70,947 cases. Trends were most pronounced in patients older than 55 years (p < 0.0001), African Americans (p < 0.0001), females (p = 0.0289), and non-Medicaid populations (p < 0.0001). Hospitalizations are seasonal with highest incidence in January through March. Hospitalizations among sarcoidosis patients have almost doubled during the past decade, with disproportionate rate increases in African Americans, women, and older patients. The rate also increases among patients with insurance other than Medicaid. This study indicates the need for heightened surveillance of sarcoidosis patients given the unknown consequences of evolving treatment approaches. Our results point to a need for research investigating risk factors for hospitalization, including medications, co-morbidities, demographics, and socioeconomic status.

International Classification of Diseases

United States - epidemiology

Age Distribution

Humans

Middle Aged

Sarcoidosis - ethnology

Cost of Illness

Hospitalization - statistics & numerical data

Logistic Models

Male

Medicaid - statistics & numerical data

Incidence

Sarcoidosis - epidemiology

Hospitalization - trends

Aged, 80 and over

Sex Distribution

Adult

Female

Aged

Retrospective Studies

Seasons

Cohort Studies

Details

Title: Subtitle: Increased hospitalizations among sarcoidosis patients from 1998 to 2008: a population-based cohort study
Creators: Alicia K Gerke - Department of Internal Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA. alicia-gerke@uiowa.edu
Ming Yang
Fan Tang
Joseph E Cavanaugh
Philip M Polgreen
Resource Type: Journal article
Publication Details: BMC pulmonary medicine, Vol.12(1), pp.19-19
DOI: 10.1186/1471-2466-12-19
PMID: 22584044
PMCID: PMC3391973
NLM abbreviation: BMC Pulm Med
ISSN: 1471-2466
eISSN: 1471-2466
Publisher: England
Grant note: 1KL2RR024980 / NCRR NIH HHS
Language: English
Date published: 07/09/2012
Academic Unit: Statistics and Actuarial Science; Pulmonary, Critical Care, and Occupational Medicine; Infectious Diseases; Epidemiology; Biostatistics; Injury Prevention Research Center; Internal Medicine
Record Identifier: 9983985835602771

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