Journal article
Increased iodine uptake in thyroid carcinoma after treatment with sodium butyrate and decitabine (5-Aza-dC)
Otolaryngology--head and neck surgery, Vol.137(5), pp.722-728
2007
DOI: 10.1016/j.otohns.2007.07.030
PMID: 17967635
Abstract
To determine if epigenetic-modifying drugs can increase iodine uptake in thyroid carcinoma cell lines.
Human thyroid carcinoma cell lines were tested for iodine uptake before and after treatment with epigenetic-modifying agents.
Thyroid carcinoma cell lines DRO and 2-7 had high levels of DNA methylation (74% and 80%) compared with normal thyroid tissue (6%) (
P < 0.05). This finding correlated with low levels of sodium iodide symporter (NIS) expression in the untreated thyroid carcinoma cell line. Combination treatment with the epigenetic-modifying agents 5-aza-2′-deoxycytidine and sodium butyrate resulted in increases in NIS messenger RNA levels, global histone acetylation, and 9- and 8-fold increases in I
125 uptake for the DRO and 2-7 cells, respectively.
Epigenetic-modifier drugs represent a novel adjuvant treatment for those patients with radioablation-resistant thyroid cancer.
Epigenetic-modifying agents show potential for treatment of radioablation-resistant thyroid cancer.
Details
- Title: Subtitle
- Increased iodine uptake in thyroid carcinoma after treatment with sodium butyrate and decitabine (5-Aza-dC)
- Creators
- Matthew J Provenzano - Department of Otolaryngology–Head and Neck Surgery, University of Iowa, Iowa City, IAMatthew P Fitzgerald - Department of Radiation Oncology, University of Iowa, Iowa City, IAKimberly Krager - Department of Radiation Oncology, University of Iowa, Iowa City, IAFrederick E Domann - Department of Radiation Oncology, University of Iowa, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- Otolaryngology--head and neck surgery, Vol.137(5), pp.722-728
- Publisher
- Mosby, Inc
- DOI
- 10.1016/j.otohns.2007.07.030
- PMID
- 17967635
- ISSN
- 0194-5998
- eISSN
- 1097-6817
- Language
- English
- Date published
- 2007
- Academic Unit
- Pathology; Surgery; Radiation Oncology
- Record Identifier
- 9984047701902771
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