Journal article
Increased leg muscle fatigability during 2 mA and 4 mA transcranial direct current stimulation over the left motor cortex
Experimental brain research, Vol.238(2), pp.333-343
02/01/2020
DOI: 10.1007/s00221-019-05721-w
PMID: 31919540
Abstract
Transcranial direct current stimulation (tDCS) using intensities <= 2 mA on physical and cognitive outcomes has been extensively investigated. Studies comparing the effects of different intensities of tDCS have yielded mixed results and little is known about how higher intensities (> 2 mA) affect outcomes. This study examined the effects of tDCS at 2 mA and 4 mA on leg muscle fatigability. This was a double-blind, randomized, sham-controlled study. Sixteen healthy young adults underwent tDCS at three randomly ordered intensities (sham, 2 mA, 4 mA). Leg muscle fatigability of both legs was assessed via isokinetic fatigue testing (40 maximal reps, 120 degrees/s). Torque- and work-derived fatigue indices (FI-T and FI-W, respectively), as well as total work performed (TW), were calculated. FI-T of the right knee extensors indicated increased fatigability in 2 mA and 4 mA compared with sham (p = 0.01, d = 0.73 and p < 0.001, d = 1.61, respectively). FI-W of the right knee extensors also indicated increased fatigability in 2 mA and 4 mA compared to sham (p = 0.01, d = 0.57 and p < 0.001, d = 1.12, respectively) and 4 mA compared with 2 mA (p = 0.034, d = 0.37). tDCS intensity did not affect TW performed. The 2 mA and 4 mA tDCS intensities increased the fatigability of the right knee extensors in young, healthy participants, potentially from altered motor unit recruitment/discharge rate or cortical hyperexcitability. Despite this increase in fatigability, the TW performed in both these conditions was not different from sham.
Details
- Title: Subtitle
- Increased leg muscle fatigability during 2 mA and 4 mA transcranial direct current stimulation over the left motor cortex
- Creators
- Craig D. Workman - University of IowaJohn Kamholz - University of IowaThorsten Rudroff - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Experimental brain research, Vol.238(2), pp.333-343
- Publisher
- Springer Nature
- DOI
- 10.1007/s00221-019-05721-w
- PMID
- 31919540
- ISSN
- 0014-4819
- eISSN
- 1432-1106
- Number of pages
- 11
- Language
- English
- Date published
- 02/01/2020
- Academic Unit
- Neurology; Psychiatry; Health and Human Physiology
- Record Identifier
- 9984259644002771
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